Methicillin-resistant Staphylococcus aureus: molecular characterization, evolution, and epidemiology

S Lakhundi, K Zhang - Clinical microbiology reviews, 2018 - Am Soc Microbiol
Staphylococcus aureus, a major human pathogen, has a collection of virulence factors and
the ability to acquire resistance to most antibiotics. This ability is further augmented by …

Overview of molecular typing methods for outbreak detection and epidemiological surveillance

AJ Sabat, A Budimir, D Nashev, R Sá-Leão… - …, 2013 - eurosurveillance.org
Typing methods for discriminating different bacterial isolates of the same species are
essential epidemiological tools in infection prevention and control. Traditional typing …

The distribution of plasmids that carry virulence and resistance genes in Staphylococcus aureus is lineage associated

AJ McCarthy, JA Lindsay - BMC microbiology, 2012 - Springer
Background Staphylococcus aureus is major human and animal pathogen. Plasmids often
carry resistance genes and virulence genes that can disseminate through S. aureus …

Extensive Horizontal Gene Transfer during Staphylococcus aureus Co-colonization In Vivo

AJ McCarthy, A Loeffler, AA Witney… - Genome biology and …, 2014 - academic.oup.com
Staphylococcus aureus is a commensal and major pathogen of humans and animals.
Comparative genomics of S. aureus populations suggests that colonization of different host …

Shift in dominant hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) clones over time

GM Knight, EL Budd, L Whitney… - Journal of …, 2012 - academic.oup.com
Objectives The majority of HA-MRSA infections are caused by endogenous infection and by
only a small number of clones. The reasons for the success of some clones over others are …

Hospital-associated MRSA and antibiotic resistance—what have we learned from genomics?

JA Lindsay - International Journal of Medical Microbiology, 2013 - Elsevier
In many parts of the world, MRSA are responsible for a high proportion of S. aureus
infections in patients in contact with healthcare. Molecular studies have shown this is due to …

Staphylococcus aureus Temperate Bacteriophage: Carriage and Horizontal Gene Transfer is Lineage Associated

AJ McCarthy, AA Witney, JA Lindsay - Frontiers in cellular and …, 2012 - frontiersin.org
Staphylococcus aureus is a major cause of human and animal infections. Bacteriophage are
a class of mobile genetic element (MGE) that carry virulence genes and disseminate them …

Staphylococcus aureus innate immune evasion is lineage-specific: a bioinfomatics study

AJ McCarthy, JA Lindsay - Infection, Genetics and Evolution, 2013 - Elsevier
Staphylococcus aureus is a major human pathogen, and is targeted by the host innate
immune system. In response, S. aureus genomes encode dozens of secreted proteins that …

Staphylococcus aureus CC398 clade associated with human-to-human transmission

AJ McCarthy, W Van Wamel… - Applied and …, 2012 - Am Soc Microbiol
Staphylococcus aureus clonal complex 398 (CC398) isolates colonize livestock and can
spread to human contacts. Genetic analysis of isolates epidemiologically associated with …

Resistance gene transfer: induction of transducing phage by sub-inhibitory concentrations of antimicrobials is not correlated to induction of lytic phage

KI Stanczak-Mrozek, KG Laing… - Journal of Antimicrobial …, 2017 - academic.oup.com
Objectives: Horizontal gene transfer of antimicrobial resistance (AMR) genes between
clinical isolates via transduction is poorly understood. MRSA are opportunistic pathogens …