Muscle fiber denervation is a major contributor to the decline in physical function observed
with aging. Denervation can occur through breakdown of the neuromuscular junctions (NMJ) …

Skeletal muscle regeneration is a complex process involving the generation of new
myofibers after trauma, competitive physical activity, or disease. In this context, adult skeletal …

This review concentrates on the biology of long-term denervated muscle, especially as it
relates to newer techniques for restoring functional mass. After denervation, muscle passes …

During aging and neuromuscular diseases, there is a progressive loss of skeletal muscle
volume and function impacting mobility and quality of life. Muscle loss is often associated …

The ability of very old animals to make new muscle after injury remains controversial. This
issue has major implications for the regenerative potential of damaged geriatric human …

The high prevalence of rotator cuff tears poses challenges to individual patients and the
healthcare system at large. This orthopedic injury is complicated further by high rates of …

Satellite cells are companions to voluntary muscle fibres, and are named for their intimate
positional orsatellite'relationship, as if revolving around fibres, like a satellite moon around …

While changes in muscle protein synthesis and degradation have long been known to
contribute to muscle wasting, a body of literature has arisen which suggests that regulation …

Myostatin (MSTN) is a muscle-specific secreted peptide that functions to limit muscle growth
through an autocrine regulatory feedback loop. Loss of MSTN activity in cattle, mice, and …

Irreversible denervation atrophy remains an unsolved clinical problem, and the role of
skeletal muscle stem cell (MuSC, satellite cell) depletion in this process is unclear. We …