Replication protein A: single‐stranded DNA's first responder: dynamic DNA‐interactions allow replication protein A to direct single‐strand DNA intermediates into …
Replication protein A (RPA), the major single‐stranded DNA‐binding protein in eukaryotic
cells, is required for processing of single‐stranded DNA (ssDNA) intermediates found in …
cells, is required for processing of single‐stranded DNA (ssDNA) intermediates found in …
Replication protein A: a multifunctional protein with roles in DNA replication, repair and beyond
R Dueva, G Iliakis - NAR cancer, 2020 - academic.oup.com
Single-stranded DNA (ssDNA) forms continuously during DNA replication and is an
important intermediate during recombination-mediated repair of damaged DNA. Replication …
important intermediate during recombination-mediated repair of damaged DNA. Replication …
TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA
RL Flynn, RC Centore, RJ O'Sullivan, R Rai, A Tse… - Nature, 2011 - nature.com
Maintenance of telomeres requires both DNA replication and telomere 'capping'by shelterin.
These two processes use two single-stranded DNA (ssDNA)-binding proteins, replication …
These two processes use two single-stranded DNA (ssDNA)-binding proteins, replication …
[HTML][HTML] Replication protein A: directing traffic at the intersection of replication and repair
GG Oakley, SM Patrick - Frontiers in bioscience: a journal and …, 2010 - ncbi.nlm.nih.gov
Since the initial discovery of replication protein A (RPA) as a DNA replication factor, much
progress has been made on elucidating critical roles for RPA in other DNA metabolic …
progress has been made on elucidating critical roles for RPA in other DNA metabolic …
Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue
Human telomere biology disorders (TBD)/short telomere syndromes (STS) are
heterogeneous disorders caused by inherited loss-of-function mutations in telomere …
heterogeneous disorders caused by inherited loss-of-function mutations in telomere …
RPA prevents G‐rich structure formation at lagging‐strand telomeres to allow maintenance of chromosome ends
J Audry, L Maestroni, E Delagoutte, T Gauthier… - The EMBO …, 2015 - embopress.org
Replication protein A (RPA) is a highly conserved heterotrimeric single‐stranded DNA‐
binding protein involved in DNA replication, recombination, and repair. In fission yeast, the …
binding protein involved in DNA replication, recombination, and repair. In fission yeast, the …
[HTML][HTML] Telomeres: structures in need of unwinding
K Paeschke, KR McDonald, VA Zakian - FEBS letters, 2010 - Elsevier
Telomeres protect the ends of eukaryotic chromosomes from being recognized and
processed as double strand breaks. In most organisms, telomeric DNA is highly repetitive …
processed as double strand breaks. In most organisms, telomeric DNA is highly repetitive …
The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro
Y Wu, VA Zakian - Proceedings of the National Academy of …, 2011 - National Acad Sciences
In Saccharomyces cerevisiae, a Cdc13–Est1 interaction is proposed to mediate recruitment
of telomerase to DNA ends. Here we provide unique in vitro evidence for this model by …
of telomerase to DNA ends. Here we provide unique in vitro evidence for this model by …
Fission yeast Ccq1 is telomerase recruiter and local checkpoint controller
Telomeres recruit telomerase and differentiate chromosome ends from sites of DNA
damage. Although the DNA damage checkpoint PI3-kinases ATM and ATR localize to …
damage. Although the DNA damage checkpoint PI3-kinases ATM and ATR localize to …
Structural variations and adaptations of synthetic chromosome ends driven by SCRaMbLE in haploid and diploid yeasts
Y Xiong, H Zhang, S Zhou, L Ma, W Xiao… - ACS Synthetic …, 2023 - ACS Publications
Variations and adaptations of chromosome ends play an important role in eukaryotic
karyotype evolution. Traditional experimental studies of the adaptations of chromosome …
karyotype evolution. Traditional experimental studies of the adaptations of chromosome …