Introduction: Colchicine has been successfully used for the treatment of neutrophilic
disorders such as familial Mediterranean fever (FMF), Behçet disease (BD) and gout. There …

Blood platelets are the key cellular players in blood clotting and thus of great biomedical
importance. While spreading at the site of injury, they reorganize their cytoskeleton within …

The cardioprotective mechanisms of colchicine in patients with stable ischemic heart
disease remain uncertain. We tested varying concentrations of colchicine on platelet activity …

Introduction Platelets activation/aggregation with subsequent thrombus formation is the main
event in the pathophysiology of acute coronary syndrome. Once activated, platelets show an …

Platelets are small anucleate blood cells involved in haemostasis. Platelet activation,
caused by agonists such as thrombin or by contact with the extracellular matrix, leads to …

The discoid form of platelets is maintained by a marginal band of tightly coiled microtubules.
β1-tubulin is the major isoform within platelet and megakaryocyte microtubules. In 24.2% of …

Atypical hemolytic uremic syndrome (aHUS) is associated with complement system
dysregulation, and more than 25% of pediatric aHUS cases are linked to mutations in …

Dielectric blood coagulometry (DBCM) is intended to support hemostasis management by
providing comprehensive information on blood coagulation from automated, time-dependent …

Flavonoids are low-molecular weight, aromatic compounds derived from fruits, vegetables,
and other plant components. The consumption of these phytochemicals has been reported …

The microtubule inhibitor and anti-inflammatory agent colchicine is used to treat a range of
conditions involving inflammasome activation in monocytes and neutrophils, and is now …