The large family of deubiquitinating enzymes (DUBs) are involved in the regulation of a
plethora of processes carried out inside the cell by protein ubiquitination. Ubiquitination is a …

Deubiquitinases (DUBs) are required for the reverse reaction of ubiquitination and act as
major regulators of ubiquitin signaling processes. Emerging evidence suggests that these …

Forty years ago, ubiquitin was first discovered as a posttranslational modification earmarking
proteins for degradation [1]. This seminal, biochemical work laid the foundation for countless …

Mitochondria are increasingly recognized as cellular hubs to orchestrate signaling pathways
that regulate metabolism, redox homeostasis, and cell fate decisions. Recent research …

Background Accumulating evidence has demonstrated that aberrant expression of
deubiquitinating enzymes is associated with the initiation and progression of Triple-negative …

Autoinflammatory diseases are a heterogenous group of disorders defined by fever and
systemic inflammation suggesting involvement of genes regulating innate immune …

Melanogenesis is a critical biochemical process in which melanocytes produce melanin, a
crucial element involved in the formation of coat colour in mammals. According to several …

Stable regulation of protein fate is a prerequisite for successful bone tissue repair. As a
ubiquitin‐specific protease (USP), USP26 can stabilize the protein fate of β‐catenin to …

Targeting nuclear factor-kappa B (NF-κB) represents a highly viable strategy against
chemoresistance in cancers as well as cell death. Ubiquitination, including linear …

Linear ubiquitination catalyzed by HOIL-1-interacting protein (HOIP), the key component of
the linear ubiquitination assembly complex, plays fundamental roles in tissue homeostasis …