Recent papers have emphasized the primary role of cellular information management in
biological and evolutionary development. In this framework, intelligent cells collectively …

Mitochondria are the powerhouse of the cell and dynamically control fundamental biological
processes including cell reprogramming, pluripotency, and lineage specification. Although …

Our understanding of pluripotency remains limited: iPSC generation has only been
established for a few model species, pluripotent stem cell lines exhibit inconsistent …

Ectopic expression of OCT4, SOX2, KLF4 and MYC (OSKM) transforms differentiated cells
into induced pluripotent stem cells. To refine our mechanistic understanding of …

Autism spectrum disorders (ASD) comprise a range of neurodevelopmental pathologies
characterized by deficits in social interaction and repetitive behaviors, collectively affecting …

Whole genome sequencing of viruses provides high-resolution molecular insights,
enhancing our understanding of viral genome function and phylogeny. Beyond fundamental …

Cell proliferation is a ubiquitous process required for organismal development and
homeostasis. However, individuals with partial loss-of-function variants in DNA replicative …

Obesity-related metabolic diseases, including obesity, diabetes, hyperlipidemia, and non-
alcoholic fatty liver diseases pose a significant threat to health. However, comprehensive …

Pluripotent stem cells are characterized by their differentiation potential toward endoderm,
mesoderm, and ectoderm. However, it is still largely unclear how these cell-fate decisions …

Acquired myeloid malignancies are a spectrum of clonal disorders known to be caused by
sequential acquisition of genetic lesions in hematopoietic stem and progenitor cells, leading …