Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …

The contribution of the immune system to idiopathic pulmonary fibrosis (IPF) remains poorly
understood. While most sources agree that IPF does not result from a primary …

Vimentin is an intermediate filament protein that plays key roles in integration of cytoskeletal
functions, and therefore in basic cellular processes such as cell division and migration …

As a member of the large family of intermediate filaments (IFs), vimentin has emerged as a
highly dynamic and versatile cytoskeletal protein involved in many key processes of wound …

The mechanisms by which environmental exposures contribute to the pathogenesis of lung
fibrosis are unclear. Here, we demonstrate an increase in cadmium (Cd) and carbon black …

Vimentin expression contributes to cellular mechanoprotection and is a widely recognized
marker of fibroblasts and of epithelial-mesenchymal transition. But it is not understood how …

The myofibroblast is a specialized fibroblast that expresses α-smooth muscle actin (α-SMA)
and participates in wound contraction and fibrosis. The fibroblast to myofibroblast transition …

Idiopathic pulmonary fibrosis (IPF) is a chronic, debilitating, fibrotic lung disease leading to
respiratory failure and ultimately to death. Being the prototype of interstitial lung diseases …

Vimentin is a protein of intermediate filament family, which is expressed in all mesenchymal
cells. Vimentin plays a key role in the physiology of the cell, cellular interactions and the …

Background & Aims Fibrosis, the primary cause of morbidity in chronic liver disease, is
induced by pro-inflammatory cytokines, immune cell infiltrates, and tissue resident cells that …