This review provides the reader a concise overview of the majority of prodrug approaches
with the emphasis on the modern approaches to prodrug design. The chemical approach …

Enzymes are highly specific biological catalysts that accelerate the rate of chemical
reactions within the cell. Our knowledge of how enzymes work remains incomplete …

It is believed that the bitter taste of paracetamol, a pain killer drug, is due to its hydroxyl
group. Hence, it is expected that blocking the hydroxy group with a suitable linker could …

DFT calculation results for intramolecular proton transfer reactions in Kirby's enzyme models
1–7 reveal that the reaction rate is quite responsive to geometric disposition, especially to …

A mechanistic study using DFT calculation methods at B3LYP/6-31G (d, p), B3LYP/311+ G
(d, p) levels and hybrid GGA (MPW1k) on an intramolecular acid catalyzed hydrolysis of …

Based on stability studies on the drugs atenolol and propranolol and some of their
derivatives it is believed that increasing the lipophilicity of the drug will lead to an increase in …

The palatability of the active ingredient of a drug is a significant obstacle in developing a
patient friendly dosage form. Organoleptic properties, such as taste, are an important factor …

DFT and ab initio calculation results for proton transfer reactions in Kirby's acetals reveal that
the mechanism proceeds via efficient intramolecular general acid catalysis (IGAC) and not …

The DFT B3LYP/6-31G (d, p) and HF/6-31G calculation results for the cyclization reactions of
six different di-substituted 4-bromobutylamines (Brown's system) reveal that the driving force …

Density Functional Theory (DFT) and ab initio calculation results for the proton transfer
reaction in Kirby's enzyme models 1‐6 reveal that the reaction rate is largely dependent on …