New thiazole carboxamide derivatives as COX inhibitors: design, synthesis, anticancer screening, in silico molecular docking, and ADME profile studies
The goal of this work was to create and test a new series of thiazole carboxamide derivatives
for their cyclooxygenase (COX) suppressor and anticancer effects. The compounds were …
for their cyclooxygenase (COX) suppressor and anticancer effects. The compounds were …
Novel indole-pyrazole hybrids as potential tubulin-targeting agents; Synthesis, antiproliferative evaluation, and molecular modeling studies
Abstract Structurally diverse indole-3-pyrazole-5-carboxamide analogues (10-29) were
designed, synthesized, and evaluated for their antiproliferative activity against three cancer …
designed, synthesized, and evaluated for their antiproliferative activity against three cancer …
Synthesis, antimicrobial activity, and molecular modeling studies of some benzoxazole derivatives
MT Muhammed, G Kuyucuklu… - Letters in Drug …, 2022 - ingentaconnect.com
Background: The need to develop novel antimicrobial agents is apparent as infectious
diseases are increasing and resistance is rapidly developing against the drugs used in the …
diseases are increasing and resistance is rapidly developing against the drugs used in the …
[PDF][PDF] Benzoxazole: progress report on chemistry, synthesis and biological activities
S Laeeq, AK Sirbaiya, HH Siddiqui - Indo American journal of …, 2013 - researchgate.net
This review article presents a survey covering the synthetic strategies leading to
benzoxazole derivatives that have shown various considerable biological activities such as …
benzoxazole derivatives that have shown various considerable biological activities such as …
Anticancer activity of thiophene carboxamide derivatives as CA-4 biomimetics: Synthesis, biological potency, 3D spheroid model, and molecular dynamics simulation
The present study aimed to synthesize thiophene carboxamide derivatives, which are
considered biomimetics of the anticancer medication Combretastatin A-4 (CA-4), and …
considered biomimetics of the anticancer medication Combretastatin A-4 (CA-4), and …
Structure-based design, synthesis, molecular docking study and biological evaluation of 1, 2, 4-triazine derivatives acting as COX/15-LOX inhibitors with anti-oxidant …
M Khoshneviszadeh, O Shahraki… - Journal of enzyme …, 2016 - Taylor & Francis
Abstract A set of 1, 2, 4-triazine derivatives were designed as cyclooxygenase-2 (COX-2)
inhibitors. These compounds were synthesized and screened for inhibition of …
inhibitors. These compounds were synthesized and screened for inhibition of …
Design, synthesis and biological evaluation of novel 1, 3-diarylpyrazoles as cyclooxygenase inhibitors, antiplatelet and anticancer agents
With the aim of achieving new compounds possessing both anti-inflammatory and
antiplatelet activities, we synthesized (E)-3-[3-(pyridin-3/4-yl)-1-(phenyl …
antiplatelet activities, we synthesized (E)-3-[3-(pyridin-3/4-yl)-1-(phenyl …
Synthesis, cytotoxicity, and molecular properties prediction of novel 1, 3-diarylpyrazole derivatives
A novel combinatorial library of ester and amide derivatives of 1, 3-diarylpyrazoles was
designed and synthesized. Anticancer activities of these compounds were assessed against …
designed and synthesized. Anticancer activities of these compounds were assessed against …
Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl) pyridazin-(2H)-3-one derivatives
A Singh, M Asif - Brazilian Journal of Pharmaceutical Sciences, 2013 - SciELO Brasil
Several 6-aryl-4-substituted benzylidene/furfurylidene pyridazin (2H)-3-one derivatives (4a-
f) were synthesized and evaluated as analgesic and anti-inflammatory agents in mice and …
f) were synthesized and evaluated as analgesic and anti-inflammatory agents in mice and …
[PDF][PDF] Synthesis and anti-inflammatory activity of novel Ketoprofen and Ibuprofen derivatives
S Al Mekhlafi, H Alkadi, MIK El-Sayed - J. Chem. Pharm. Res, 2015 - researchgate.net
The major side effects associated with all currently available NSAIDS are gastrointestinal
tract (GIT) hemorrhage and ulceration, due to inhibition of COX-1, which is responsible for …
tract (GIT) hemorrhage and ulceration, due to inhibition of COX-1, which is responsible for …