Recent advances in cancer immunotherapy—ranging from immune-checkpoint blockade
therapy to adoptive cellular therapy and vaccines—have revolutionized cancer treatment …

The remarkable capacity of immunotherapies to induce durable regression in some patients
with metastatic cancer relies heavily on T cell recognition of tumor-presented antigens. As …

Multiple nanotherapeutics have been approved for patients with cancer, but their effects on
survival have been modest and, in some examples, less than those of other approved …

CD8+ T cells specific for cancer cells are detected within tumours. However, despite their
presence, tumours progress. The clinical success of immune checkpoint blockade and …

Genetically engineered T cell therapy can induce remarkable tumor responses in
hematologic malignancies. However, it is not known if this type of therapy can be applied …

Adoptive cell transfer (ACT) with neoantigen-reactive T lymphocytes can mediate cancer
regression. Here we isolated unique, personalized, neoantigen-reactive T cell receptors …

Cancer elimination in humans can be achieved with immunotherapy that relies on T
lymphocyte-mediated recognition of tumor antigens. Several types of these antigens have …

It is a sad fact that despite being almost completely preventable through human
papillomavirus (HPV) vaccination and screening, cervical cancer remains the fourth most …

Recent advances in several areas are rekindling interest and enabling progress in the
development of therapeutic cancer vaccines. These advances have been made in target …

The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects,
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …