The steadfast advance of the synthetic biology field has enabled scientists to use genetically
engineered cells, instead of small molecules or biologics, as the basis for the development …

To support an ever-increasing population, modern agriculture faces numerous challenges
that pose major threats to global food and energy security. Plant-associated microbes, with …

Transcription rates are regulated by the interactions between RNA polymerase, sigma factor,
and promoter DNA sequences in bacteria. However, it remains unclear how non-canonical …

Engineered living materials could have the capacity to self-repair and self-replicate, sense
local and distant disturbances in their environment, and respond with functionalities for …

Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …

Ultrasound allows imaging at a much greater depth than optical methods, but existing
genetically encoded acoustic reporters for in vivo cellular imaging have been limited by poor …

Engineered genetic systems are prone to failure when their genetic parts contain repetitive
sequences. Designing many nonrepetitive genetic parts with desired functionalities remains …

Efficient genome engineering is critical to understand and use microbial functions. Despite
recent development of tools such as CRISPR-Cas gene editing, efficient integration of …

Over the past thirty years, since the dawn of metagenomic studies, a completely new (micro)
universe was revealed, with the potential to have profound impacts on many aspects of the …

Cell‐based biosensors offer cheap, portable and simple methods of detecting molecules of
interest but have yet to be truly adopted commercially. Issues with their performance and …