Biophysical characterization of protein–protein interactions involving disordered proteins is
challenging. A common simplification is to measure the thermodynamics and kinetics of …

An important goal of biological research is to explain and hopefully predict cell behavior
from the molecular properties of cellular components. Accordingly, much work was done to …

Electrostatic interactions can strongly increase the efficiency of protein complex formation.
The charge distribution in redox proteins is often optimized to steer a redox partner to the …

The HECT domain of HECT E3 ligases consists of flexibly linked N-and C-terminal lobes,
with a ubiquitin (Ub) donor site on the C-lobe that is directly involved in substrate …

One requirement for the survival and reproduction of living organisms is the ability to receive
external stimuli and then respond appropriately. It is increasingly understood that …

Understanding protein complex formation: the role of charge distribution in the Understanding
protein complex formation: the role of charge distribution in the encounter complex Di Sa ino …

Specific molecular recognition is a basic requirement for life. In physical terms, the source of
interaction specificity that favors a small set of specific interactions over the multitude of …