Bacterial vaginosis: drivers of recurrence and challenges and opportunities in partner treatment

LA Vodstrcil, CA Muzny, EL Plummer, JD Sobel… - BMC medicine, 2021 - Springer
Bacterial vaginosis (BV) is the most common vaginal dysbiosis to affect women globally, yet
an unacceptably high proportion of women experience BV recurrence within 6 months of …

Determinants of vaginal microbiota composition

Y Moosa, D Kwon, T De Oliveira… - Frontiers in cellular and …, 2020 - frontiersin.org
There is increasing evidence that the composition of a woman's vaginal microbiota
significantly influences her sexual and reproductive health, including her risk of miscarriage …

Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression

DJ Delgado-Diaz, B Jesaveluk, JA Hayward, D Tyssen… - Microbiome, 2022 - Springer
Background Women with a cervicovaginal microbiota dominated by Lactobacillus spp. are at
reduced risk of acquiring sexually transmitted infections including HIV, but the biological …

The complex link between the female genital microbiota, genital infections, and inflammation

S Dabee, JAS Passmore, R Heffron… - Infection and …, 2021 - Am Soc Microbiol
The female genital tract microbiota is part of a complex ecosystem influenced by several
physiological, genetic, and behavioral factors. It is uniquely linked to a woman's mucosal …

Vaginal dysbiotic microbiome in women with no symptoms of genital infections

R Pramanick, N Nathani, H Warke… - Frontiers in Cellular …, 2022 - frontiersin.org
The vaginal microbiome plays a critical role in determining the progression of female genital
tract infections; however, little is known about the vaginal microbiota of Indian women. We …

Ethnic disparity in diagnosing asymptomatic bacterial vaginosis using machine learning

C Celeste, D Ming, J Broce, DP Ojo, E Drobina… - NPJ Digital …, 2023 - nature.com
While machine learning (ML) has shown great promise in medical diagnostics, a major
challenge is that ML models do not always perform equally well among ethnic groups. This …

A bibliometric analysis of the global impact of metaproteomics research

AA Ascandari, S Aminu, NEH Safdi, A El Allali… - Frontiers in …, 2023 - frontiersin.org
Background Metaproteomics is a subfield in meta-omics that is used to characterize the
proteome of a microbial community. Despite its importance and the plethora of publications …

Advances in the clinical use of metaproteomics

M Wolf, K Schallert, L Knipper, A Sickmann… - Expert review of …, 2023 - Taylor & Francis
Introduction Investigating the taxonomic and functional composition of human microbiomes
can aid in the understanding of disease etiologies, diagnosis, and therapy monitoring for …

[HTML][HTML] Moving beyond DNA: towards functional analysis of the vaginal microbiome by non-sequencing-based methods

GDS Correia, JR Marchesi, DA MacIntyre - Current Opinion in Microbiology, 2023 - Elsevier
Over the last two decades, sequencing-based methods have revolutionised our
understanding of niche-specific microbial complexity. In the lower female reproductive tract …

Deoxycholic acid-chitosan coated liposomes combined with in situ colonic gel enhances renal fibrosis therapy of emodin

Z Xu, Y Hou, J Sun, L Zhu, Q Zhang, W Yao, X Fan… - Phytomedicine, 2022 - Elsevier
Background Renal fibrosis is the final common pathological feature of various chronic
kidney diseases (CKD). Despite recent advances, development of new treatments strategy is …