[HTML][HTML] High-density lipoprotein (HDL) functionality and its relevance to atherosclerotic cardiovascular disease

CE Kosmas, I Martinez, A Sourlas, KV Bouza… - Drugs in …, 2018 - ncbi.nlm.nih.gov
Several prospective epidemiological studies have shown that there is a clear inverse
relationship between serum high-density lipoprotein-cholesterol (HDL-C) concentrations …

[HTML][HTML] High density lipoproteins: Measurement techniques and potential biomarkers of cardiovascular risk

A Hafiane, J Genest - BBA clinical, 2015 - Elsevier
Plasma high density lipoprotein cholesterol (HDL) comprises a heterogeneous family of
lipoprotein species, differing in surface charge, size and lipid and protein compositions …

Anti-inflammatory effects of HDL (high-density lipoprotein) in macrophages predominate over proinflammatory effects in atherosclerotic plaques

P Fotakis, V Kothari, DG Thomas… - … , and vascular biology, 2019 - Am Heart Assoc
Objective: HDL (high-density lipoprotein) infusion reduces atherosclerosis in animal models
and is being evaluated as a treatment in humans. Studies have shown either anti-or …

LDL‐cholesterol versus HDL‐cholesterol in the atherosclerotic plaque: inflammatory resolution versus thrombotic chaos

L Badimon, G Vilahur - Annals of the New York Academy of …, 2012 - Wiley Online Library
Atherosclerosis is a complex disease in which many processes contribute to lesion
development. Yet, it is well accepted that high serum levels of low‐density lipoproteins (LDL) …

HDL dysfunction in diabetes: causes and possible treatments

D Farbstein, AP Levy - Expert review of cardiovascular therapy, 2012 - Taylor & Francis
HDL is known to be inversely correlated with cardiovascular disease due to its diverse
antiatherogenic functions. These functions include cholesterol efflux and reverse cholesterol …

Novel anti-inflammatory therapies for the treatment of atherosclerosis

R Khan, V Spagnoli, JC Tardif, PL L'Allier - Atherosclerosis, 2015 - Elsevier
The underlying role of inflammation in atherosclerosis has been characterized. However,
current treatment of coronary artery disease (CAD) predominantly consists of targeted …

Dysfunctional high-density lipoproteins in coronary heart disease: implications for diagnostics and therapy

W Annema, A von Eckardstein - Translational Research, 2016 - Elsevier
Low plasma levels of high-density lipoprotein (HDL) cholesterol are associated with
increased risks of coronary heart disease. HDL mediates cholesterol efflux from …

The positive side of the Alzheimer's disease amyloid cross-interactions: the case of the Aβ 1-42 peptide with tau, TTR, CysC, and ApoA1

L Ciccone, C Shi, D Di Lorenzo, AC Van Baelen… - Molecules, 2020 - mdpi.com
Alzheimer's disease (AD) represents a progressive amyloidogenic disorder whose
advancement is widely recognized to be connected to amyloid-β peptides and Tau …

Unravelling HDL—looking beyond the cholesterol surface to the quality within

S Kajani, S Curley, FC McGillicuddy - International journal of molecular …, 2018 - mdpi.com
High-density lipoprotein (HDL) particles have experienced a turbulent decade of falling from
grace with widespread demotion from the most-sought-after therapeutic target to reverse …

Nanomedicine-based strategies for treatment of atherosclerosis

M Schiener, M Hossann, JR Viola… - Trends in molecular …, 2014 - cell.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall that arises from an
imbalanced lipid metabolism and a maladaptive inflammatory response. Despite intensive …