Background Desirability of outcome ranking (DOOR) outcomes, with or without response
adjusted for antibiotic risk (RADAR), are increasingly used in infectious diseases …

Successful antimicrobial therapy depends on achieving optimal drug concentrations within
individual patients. Inter-patient variability in pharmacokinetics (PK) and differences in …

Introduction Recent studies show that antibiotic therapy is safe and feasible for CT-
confirmed uncomplicated acute appendicitis. Spontaneous resolution of acute appendicitis …

Background Prolonged antimicrobial drug (AMD) treatment is associated with antimicrobial
resistance development. Biomarker measurement may aid treatment decision‐making …

Abstract Background Randomized clinical trials (RCTs) in hospital-acquired and ventilator-
associated bacterial pneumonia (HABP and VABP, respectively) are important for the …

Nonsurgical periodontal therapy with adjunctive use of systemic antimicrobials (for 7–14
days) showed improved clinical, microbiological and immunological results over the …

Background: Antimicrobial stewardship interventions to curtail the use of third-generation
cephalosporins and antipseudomonal penicillins for the treatment of complicated …

Background Current clinical trials of new antibiotics facilitate bringing new drugs to market
but often fail to provide useful information for clinical decision making. Methods Literature …

Background: Treatment outcomes in studies on prosthetic joint infection are generally
assessed using a dichotomous outcome relating to treatment success or failure. These …

Desirability of outcome ranking (DOOR) has been developed for assessing desirability of
outcome in interventional studies. However, its possible use in observational studies of the …