As one of the most successful therapeutic target families, G protein-coupled receptors
(GPCRs) have experienced a transformation from random ligand screening to knowledge …

The worldwide emergence of New Delhi metallo-β-lactamase-1 (NDM-1) as a
carbapenemase able to hydrolyze nearly all available β-lactam antibiotics has characterized …

The growing number of bacterial pathogens that are resistant to numerous antibiotics is a
cause for concern around the globe. There have been no new broad‐spectrum antibiotics …

Affinity selection-mass spectrometry (AS-MS) is a high-throughput screening (HTS)
technique for drug discovery that enables rapid screening of large collections of compounds …

Covering: 2000 to 2016 Natural product extracts are a rich source of bioactive compounds.
As a result, the screening of natural products for the identification of novel biologically active …

We report the discovery of a promising NDM-1 inhibitor, ebselen, through a cell-based
screening approach. Enzymatic kinetic study and ESI-MS analysis suggested that ebselen …

Infections by carbapenem-resistant Enterobacteriaceae are difficult to manage owing to
broad antibiotic resistance profiles and because of the inability of clinically used β …

In this study, a new method based on ultrafiltration liquid chromatography-mass
spectrometry (UF-LC–MS) combined with enzyme channel blocking (ECB) was developed …

Misoprostol is a life-saving drug in many developing countries for women at risk of post-
partum hemorrhaging owing to its affordability, stability, ease of administration and clinical …

Since its discovery in 2008, New Delhi metallo-β-lactamase-1 (NDM-1)-producing
Enterobacteriaceae have disseminated globally, facilitated predominantly by gut …