Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
[HTML][HTML] A structural view of the SARS-CoV-2 virus and its assembly
NJ Hardenbrook, P Zhang - Current opinion in virology, 2022 - Elsevier
Highlights•Structural biology plays a vital role in SARS-CoV-2 vaccine and treatment.•High-
resolution structures of SARS-CoV-2 proteins and complexes have been obtained.•In situ …
resolution structures of SARS-CoV-2 proteins and complexes have been obtained.•In situ …
Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice
New variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to
arise and prolong the coronavirus disease 2019 (COVID-19) pandemic. Here, we used a …
arise and prolong the coronavirus disease 2019 (COVID-19) pandemic. Here, we used a …
Evolution of SARS-CoV-2 variants: implications on immune escape, vaccination, therapeutic and diagnostic strategies
NZ Zabidi, HL Liew, IA Farouk, A Puniyamurti, AJW Yip… - Viruses, 2023 - mdpi.com
The COVID-19 pandemic caused by SARS-CoV-2 is associated with a lower fatality rate
than its SARS and MERS counterparts. However, the rapid evolution of SARS-CoV-2 has …
than its SARS and MERS counterparts. However, the rapid evolution of SARS-CoV-2 has …
An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif
The rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
such as the Omicron variants that are highly transmissible and immune evasive …
such as the Omicron variants that are highly transmissible and immune evasive …
Distinct patterns of SARS-CoV-2 BA. 2.87. 1 and JN. 1 variants in immune evasion, antigenicity, and cell-cell fusion
The rapid evolution of SARS-CoV-2 variants presents a constant challenge to the global
vaccination effort. In this study, we conducted a comprehensive investigation into two newly …
vaccination effort. In this study, we conducted a comprehensive investigation into two newly …
SARS‐CoV‐2 variants preferentially emerge at intrinsically disordered protein sites helping immune evasion
The SARS‐CoV‐2 pandemic is maintained by the emergence of successive variants,
highlighting the flexibility of the protein sequences of the virus. We show that experimentally …
highlighting the flexibility of the protein sequences of the virus. We show that experimentally …
A broadly reactive antibody targeting the N-terminal domain of SARS-CoV-2 spike confers Fc-mediated protection
Most neutralizing anti-SARS-CoV-2 monoclonal antibodies (mAbs) target the receptor
binding domain (RBD) of the spike (S) protein. Here, we characterize a panel of mAbs …
binding domain (RBD) of the spike (S) protein. Here, we characterize a panel of mAbs …
Cryptic-site-specific antibodies to the SARS-CoV-2 receptor binding domain can retain functional binding affinity to spike variants
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has accumulated more than
700 million infection cases and 6.9 million deaths. New variants have affected antibody …
700 million infection cases and 6.9 million deaths. New variants have affected antibody …
A High-Avidity, Thermostable, and Low-Cost Synthetic Capture for Ultrasensitive Detection and Quantification of Viral Antigens and Aerosols
Lateral flow assays (LFAs) are currently the most popular point-of-care diagnostics, rapidly
transforming disease diagnosis from expensive doctor checkups and laboratory-based tests …
transforming disease diagnosis from expensive doctor checkups and laboratory-based tests …