Major developments in research into the azole class of antifungal agents during the 1990s
have provided expanded options for the treatment of many opportunistic and endemic fungal …

In the past decade, the frequency of diagnosed fungal infections has risen sharply due to
several factors, including the increase in the number of immunosuppressed patients …

Cryptococcosis is a global invasive mycosis associated with significant morbidity and
mortality. These guidelines for its management have been built on the previous Infectious …

The availability of new antifungal agents with novel mechanisms of action has stimulated
renewed interest in combination antifungal therapies. In particular, and despite the limited …

In certain unique clinical settings, the ability of the antimicrobial agent administered to kill the
pathogen outright may be quite important. These situations invariably involve infection of a …

Cryptococcus neoformans strains classically have been grouped into two varieties that
included five serotypes known as C. neoformans variety neoformans (serotypes A, D, and …

The persistence of high morbidity and mortality from systemic fungal infections despite the
availability of novel antifungals points to the need for effective treatment strategies …

While the incidence of cryptococccal meningitis in the developed world has declined with
widespread, early antiretroviral therapy (ART), cryptococcal disease remains a major …

Background. Cryptococcal meningitis is a major cause of human immunodeficiency virus
(HIV)–associated morbidity and mortality in Africa. Improved oral treatment regimens are …

Current, widely accepted guidelines for the management of HIV-associated cryptococcal
meningoencephalitis (CM) recommend amphotericin B combined with flucytosine (5-FC) …