Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …

Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet
of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular …

Lysosomes serve dual antagonistic functions in cells by mediating anabolic growth signaling
and the catabolic turnover of macromolecules. How these janus-faced activities are …

Phosphoinositides (PIs) are phospholipids that perform crucial cell functions, ranging from
cell migration and signaling to membrane trafficking, by serving as signposts of …

Phosphoinositides (PI s) form a minor class of phospholipids with crucial functions in cell
physiology, ranging from cell signalling and motility to a role as signposts of compartmental …

Chemical neurotransmission is the major mechanism of neuronal communication.
Neurotransmitters are released from secretory organelles, the synaptic vesicles (SVs) via …

Phagocytosis is a dynamic process that requires an intricate interplay between phagocytic
receptors, membrane lipids, and numerous signalling proteins and their effectors, to …

Luminal pH and the distinctive distribution of phosphatidylinositol phosphate (PIP) lipids are
central identifying features of organelles in all eukaryotic cells that are also critical for …

Highlights•Optogenetic tools provide precise spatial and temporal control of GPCR
signaling.•Light-sensitive proteins can be engineered for GPCR-specific applications.• …

Adipocytes store nutrients as lipid droplets (LDs), but how they organize their LD stores to
balance lipid uptake, storage, and mobilization remains poorly understood. Here, using …