Physical forces are ubiquitous in biological processes across scales and diverse contexts.
This review highlights the significance of mechanical forces in nervous system development …

Peripheral nerve injury (PNI) remains an intractable challenge in regenerative medicine.
Recently, physical cue‐based strategies (eg, electrical neurostimulation, acoustic radiation …

Since the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a
significant amount of research conducted to explore its regulatory role in the physiology and …

A neuron's regenerative capacity is governed by its intrinsic and extrinsic environment. Both
peripheral and central neurons exhibit cell-type-dependent axon regeneration, but the …

Studies have probed nanoplastic toxicity on environmental organisms, but the regulatory
role of animal PIEZO-type mechanosensitive ion channel component (PIEZO) remains …

Dendrites are injured in a variety of clinical conditions such as traumatic brain and spinal
cord injuries and stroke. How neurons detect injury directly to their dendrites to initiate a pro …

We report a role for activity in the development of the primary sensory neurons that detect
touch. Genetic deletion of Piezo2, the principal mechanosensitive ion channel in …

Background Physical exercise directly stretching the peripheral nerve promotes nerve
regeneration; however, its action mechanism remains elusive. Our present study aimed to …

The Piezo1 mechanosensitive ion channel is abundant on several elements of the central
nervous system including astrocytes. It has been already demonstrated that activation of …

The monocyte–macrophage system plays an important role in phagocytosis of pathogens
and cellular debris following infection or tissue injury in several pathophysiological …