The natural product berberine (BBR) has become a potential drug in the treatment of
diabetes, hyperlipidemia, and cancer. However, the oral delivery of BBR is challenged by its …

Oral chemotherapy is an important topic in the 21st century medicine, which may radically
change the current regimen of chemotherapy and greatly improve the quality of life of the …

P-glycoprotein actively transports structurally unrelated compounds out of cells, conferring
the multidrug resistance phenotype in cancer. Tariquidar is a potent, specific …

ATP-binding cassette (ABC) transporters, P-glycoprotein (P-gp, ABCB1) and ABCG2, are
membrane proteins that couple the energy derived from ATP hydrolysis to efflux many …

P-glycoprotein (ABCB1) and breast cancer resistance protein [BCRP (also known as
ABCG2)] are drug efflux transporters of the ATP binding cassette (ABC) family of proteins …

Drug interactions are an ongoing concern in treatment of cancer, especially when cytotoxic
drugs are being used. However, the clinical relevance of these interactions is not always …

Learning Objectives After completing this course, the reader will be able to: Identify
important sources of variability in drug exposure caused by drug interactions mediated by P …

Paclitaxel and docetaxel are active against a range of human cancers. Their antitumor
activity is based on stabilization of the microtubule dynamics and thereby disruption of the …

Human jejunal permeability (P eff) is determined in the intestinal region with the highest
expression of carrier proteins and largest surface area. Intestinal P eff are often based on …

Activating mutations of the B-RAF gene are observed in> 60% of human melanomas.
Approximately 90% of these mutations occur in the activation segment of the kinase domain …