Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Metastasis or the progression of malignancy poses a major challenge in cancer therapy and
is the principal reason for increased mortality. The epithelial-mesenchymal transition (EMT) …

Cancer relapse after chemotherapy remains a main cause of cancer-related death. Although
the relapse is thought to result from the propagation of resident cancer stem cells, a lack of …

Anemia is common in colorectal cancer (CRC) but its relationships with tumor
characteristics, systemic inflammation, and survival have not been well characterized. In this …

Type XVII collagen (COL17) is a transmembrane protein located at the epidermal basement
membrane zone. COL17 deficiency results in premature hair aging phenotypes and in …

Recent studies have reported of an association between high serum apolipoprotein A1
(APOA1) levels and favorable prognosis in several malignancies, while the significance of …

Tumors are often characterized by hypoxia, vascular abnormalities, low extracellular pH,
increased interstitial fluid pressure, altered choline-phospholipid metabolism, and aerobic …

Introduction: Extracellular matrix (ECM) remodeling of the intestinal tissue is important in
inflammatory bowel disease (IBD) due to the extensive mucosal remodeling. There are still …

Background Cancer cachexia is a complex wasting syndrome affecting patients with
advanced cancer, with systemic inflammation as a key component in pathogenesis. Protein …

The cellular microenvironment composition and changes therein play an extremely
important role in cancer development. Changes in the extracellular matrix (ECM), which …