Bioactive synthetic polymers

K Jung, N Corrigan, EHH Wong, C Boyer - Advanced Materials, 2022 - Wiley Online Library
Synthetic polymers are omnipresent in society as textiles and packaging materials, in
construction and medicine, among many other important applications. Alternatively, natural …

Mucus-inspired dynamic hydrogels: Synthesis and future perspectives

R Bej, R Haag - Journal of the American Chemical Society, 2022 - ACS Publications
Mucus hydrogels at biointerfaces are crucial for protecting against foreign pathogens and for
the biological functions of the underlying cells. Since mucus can bind to and host both …

Polysulfates Block SARS‐CoV‐2 Uptake through Electrostatic Interactions

C Nie, P Pouyan, D Lauster, J Trimpert… - Angewandte Chemie …, 2021 - Wiley Online Library
Here we report that negatively charged polysulfates can bind to the spike protein of SARS‐
CoV‐2 via electrostatic interactions. Using a plaque reduction assay, we compare inhibition …

Polyglycerols as multi-functional platforms: synthesis and biomedical applications

P Pouyan, M Cherri, R Haag - Polymers, 2022 - mdpi.com
The remarkable and unique characteristics of polyglycerols (PG) have made them an
attractive candidate for many applications in the biomedical and pharmaceutical fields. The …

Polymers inspired by heparin and heparan sulfate for viral targeting

M Hoffmann, NL Snyder, L Hartmann - Macromolecules, 2022 - ACS Publications
Heparin (HP) and heparan sulfate (HS) are linear, anionically charged polysaccharides well-
known for their diverse biological activities. While HP is generally localized in mast cells and …

Functionalized Fullerene for Inhibition of SARS‐CoV‐2 Variants

TM Page, C Nie, L Neander, TL Povolotsky, AK Sahoo… - small, 2023 - Wiley Online Library
As virus outbreaks continue to pose a challenge, a nonspecific viral inhibitor can provide
significant benefits, especially against respiratory viruses. Polyglycerol sulfates recently …

Design of Glycopolymers for Controlling the Interactions with Lectins

M Nagao, H Matsumoto, Y Miura - Chemistry–An Asian Journal, 2023 - Wiley Online Library
Carbohydrates are involved in life activities through the interactions with their corresponding
proteins (lectins). Pathogen infection and the regulation of cell activity are controlled by the …

Molecular insights into site-specific interferon-α2a bioconjugates originated from PEG, LPG, and PEtOx

N Hauptstein, P Pouyan, J Kehrein, M Dirauf… - …, 2021 - ACS Publications
Conjugation of biologics with polymers modulates their pharmacokinetics, with polyethylene
glycol (PEG) as the gold standard. We compared alternative polymers and two types of …

Mucus‐Inspired Self‐Healing Hydrogels: A Protective Barrier for Cells against Viral Infection

R Bej, CA Stevens, C Nie, K Ludwig… - Advanced …, 2024 - Wiley Online Library
Mucus is a dynamic biological hydrogel, composed primarily of the glycoprotein mucin,
exhibits unique biophysical properties and forms a barrier protecting cells against a broad …

Volume overlap variation within hyperbranched polymer brushes resolves topology effects against protein fouling

Y He, S Xing, P Jiang, Y Zhao, L Chen - Biomacromolecules, 2022 - ACS Publications
Hyperbranched polymer brushes with a three-dimensional dendritic structure are used in
antifouling applications to obtain bioinert and compact dendritic structures. Though …