[HTML][HTML] The chemistry of snake venom and its medicinal potential

AL Oliveira, MF Viegas, SL da Silva… - Nature Reviews …, 2022 - nature.com
The fascination and fear of snakes dates back to time immemorial, with the first scientific
treatise on snakebite envenoming, the Brooklyn Medical Papyrus, dating from ancient Egypt …

Sabatier principle for rationalizing enzymatic hydrolysis of a synthetic polyester

J Arnling Bååth, K Jensen, K Borch, P Westh, J Kari - Jacs Au, 2022 - ACS Publications
Interfacial enzyme reactions are common in Nature and in industrial settings, including the
enzymatic deconstruction of poly (ethylene terephthalate)(PET) waste. Kinetic descriptions …

Mutexa: a computational ecosystem for intelligent protein engineering

ZJ Yang, Q Shao, Y Jiang, C Jurich, X Ran… - Journal of Chemical …, 2023 - ACS Publications
Protein engineering holds immense promise in shaping the future of biomedicine and
biotechnology. This Review focuses on our ongoing development of Mutexa, a …

Protein-Glutaminase engineering based on isothermal compressibility perturbation for enhanced modification of soy protein isolate

N Zheng, M Long, Z Zhang, Q Zan, T Osire… - Journal of Agricultural …, 2022 - ACS Publications
Protein-glutaminase plays a significant role in future food (eg, plant-based meat) processing
as a result of its ability to improve the solubility, foaming, emulsifying, and gel properties of …

Physical constraints and functional plasticity of cellulases

J Kari, GA Molina, KS Schaller… - Nature …, 2021 - nature.com
Enzyme reactions, both in Nature and technical applications, commonly occur at the
interface of immiscible phases. Nevertheless, stringent descriptions of interfacial enzyme …

Virtual bioprospecting of interfacial enzymes: relating sequence and kinetics

KS Schaller, GA Molina, J Kari, C Schiano-di-Cola… - ACS …, 2022 - ACS Publications
Deposition of enzyme sequences greatly outruns any possibility of thorough experimental
characterization. There seems to be a particular shortage of quantitative kinetic data, and …

Modern computational methods for rational enzyme engineering

P Ferreira, PA Fernandes, MJ Ramos - Chem Catalysis, 2022 - cell.com
Biocatalysis is a thriving field of research because of the vast, environmentally friendly
impact that enzymes have on industry and biotechnology. However, in most production …

Interfacial enzyme kinetics reveals degradation mechanisms behind resistant starch

Y Tian, Y Wang, X Liu, K Herburger, P Westh… - Food …, 2023 - Elsevier
The digestive resistance of so-called resistant starch (RS) provides an important nutritional
principle. However, as yet the mechanisms underlying digestive resistance of the granular …

Lipase A from Bacillus subtilis: Substrate Binding, Conformational Dynamics, and Signatures of a Lid

S Behera, S Balasubramanian - Journal of Chemical Information …, 2023 - ACS Publications
Protein–ligand binding studies are crucial for understanding the molecular basis of
biological processes and for further advancing industrial biocatalysis and drug discovery …

Computational Exploration of How Enzyme XimE Converts Natural S-Epoxide to Pyran and R-Epoxide to Furan

C Jiang, BB He, RL Zhao, MJ Xu, KN Houk… - ACS …, 2021 - ACS Publications
Enzymes have long been characterized for their specificity and efficiency in catalyzing one
substrate to one product. However, a SnoaL-like cyclase (XimE) that was originally …