Simple, efficient and thorough shotgun proteomic analysis with PatternLab V
Shotgun proteomics aims to identify and quantify the thousands of proteins in complex
mixtures such as cell and tissue lysates and biological fluids. This approach uses liquid …
mixtures such as cell and tissue lysates and biological fluids. This approach uses liquid …
[HTML][HTML] Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages
The Krebs cycle-derived metabolite itaconate and its derivatives suppress the inflammatory
response in pro-inflammatory" M1" macrophages. However, alternatively activated" M2" …
response in pro-inflammatory" M1" macrophages. However, alternatively activated" M2" …
[HTML][HTML] Mass spectrometry-based structural virology
Here we review recent developments in mass spectrometry that have enabled its growing
contribution to the field of structural virology. Evidently, there is a strong renewed general …
contribution to the field of structural virology. Evidently, there is a strong renewed general …
[HTML][HTML] ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids
Branched fatty acid (FA) esters of hydroxy FAs (HFAs; FAHFAs) are recently discovered
lipids that are conserved from yeast to mammals,. A subfamily, palmitic acid esters of …
lipids that are conserved from yeast to mammals,. A subfamily, palmitic acid esters of …
[HTML][HTML] Deubiquitinase-targeting chimeras for targeted protein stabilization
NJ Henning, L Boike, JN Spradlin, CC Ward… - Nature chemical …, 2022 - nature.com
Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These
diseases would be therapeutically benefited by targeted protein stabilization (TPS). Here we …
diseases would be therapeutically benefited by targeted protein stabilization (TPS). Here we …
[HTML][HTML] An acetylation switch of the NLRP3 inflammasome regulates aging-associated chronic inflammation and insulin resistance
It is well documented that the rate of aging can be slowed, but it remains unclear to which
extent aging-associated conditions can be reversed. How the interface of immunity and …
extent aging-associated conditions can be reversed. How the interface of immunity and …
[HTML][HTML] Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor
K Freeman-Cook, RL Hoffman, N Miller, J Almaden… - Cancer cell, 2021 - cell.com
Summary The CDK4/6 inhibitor, palbociclib (PAL), significantly improves progression-free
survival in HR+/HER2− breast cancer when combined with anti-hormonals. We sought to …
survival in HR+/HER2− breast cancer when combined with anti-hormonals. We sought to …
Rational chemical design of molecular glue degraders
ES Toriki, JW Papatzimas, K Nishikawa… - ACS central …, 2023 - ACS Publications
Targeted protein degradation with molecular glue degraders has arisen as a powerful
therapeutic modality for eliminating classically undruggable disease-causing proteins …
therapeutic modality for eliminating classically undruggable disease-causing proteins …
Harnessing the anti-cancer natural product nimbolide for targeted protein degradation
Nimbolide, a terpenoid natural product derived from the Neem tree, impairs cancer
pathogenicity; however, the direct targets and mechanisms by which nimbolide exerts its …
pathogenicity; however, the direct targets and mechanisms by which nimbolide exerts its …
[HTML][HTML] Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs
Abstract SARS-CoV-2 ORF3a is a putative viral ion channel implicated in autophagy
inhibition, inflammasome activation and apoptosis. 3a protein and anti-3a antibodies are …
inhibition, inflammasome activation and apoptosis. 3a protein and anti-3a antibodies are …