The development of the mammalian cerebellum is orchestrated by both cell-autonomous
programs and inductive environmental influences. Here, we describe the main processes of …

Post-mortem studies allow for the direct investigation of brain tissue in those with autism and
related disorders. Several review articles have focused on aspects of post-mortem …

Myelin is a defining feature of the vertebrate nervous system. Variability in the thickness of
the myelin envelope is a structural feature affecting the conduction of neuronal signals …

Doublecortin (DCX) is required for normal migration of neurons into the cerebral cortex,
since mutations in the human gene cause a disruption of cortical neuronal migration. To …

During embryonic development and adulthood, Reelin exerts several important functions in
the brain including the regulation of neuronal migration, dendritic growth and branching …

Background Reelin (RELN) is a glycoprotein secreted preferentially by cortical γ-
aminobutyric acid-ergic (GABAergic) interneurons (layers I and II) that binds to integrin …

Recently, we and others reported that the doublecortin gene is responsible for X-linked
lissencephaly and subcortical laminar heterotopia. Here, we show that Doublecortin is …

Layering of neurons in the cerebral cortex and cerebellum requires Reelin, an extracellular
matrix protein, and mammalian Disabled (mDab1), a cytosolic protein that activates tyrosine …

▪ Abstract The forebrain comprises an intricate set of structures that are required for some of
the most complex and evolved functions of the mammalian brain. As a reflection of its …

The molecular bases of brain development and CNS malignancies remain poorly
understood. Here we show that Sonic hedgehog (Shh) signaling controls the development …