Stress effects on neuronal structure: hippocampus, amygdala, and prefrontal cortex
BS McEwen, C Nasca, JD Gray - Neuropsychopharmacology, 2016 - nature.com
The hippocampus provided the gateway into much of what we have learned about stress
and brain structural and functional plasticity, and this initial focus has expanded to other …
and brain structural and functional plasticity, and this initial focus has expanded to other …
Understanding the pathophysiology of depression: From monoamines to the neurogenesis hypothesis model-are we there yet?
E Jesulola, P Micalos, IJ Baguley - Behavioural brain research, 2018 - Elsevier
A number of factors (biogenic amine deficiency, genetic, environmental, immunologic,
endocrine factors and neurogenesis) have been identified as mechanisms which provide …
endocrine factors and neurogenesis) have been identified as mechanisms which provide …
Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in …
A Du Preez, D Onorato, I Eiben, K Musaelyan… - Brain, behavior, and …, 2021 - Elsevier
Unpredictable chronic mild stress (UCMS) is one of the most commonly used, robust and
translatable models for studying the neurobiological basis of major depression. Although the …
translatable models for studying the neurobiological basis of major depression. Although the …
Neural basis of major depressive disorder: Beyond monoamine hypothesis
The monoamine hypothesis has been accepted as the most common hypothesis of major
depressive disorder (MDD) for a long period because of its simplicity and understandability …
depressive disorder (MDD) for a long period because of its simplicity and understandability …
Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects
Chronic stressful life events are risk factors for developing major depression, the
pathophysiology of which is strongly linked to impairments in serotonin (5-HT) …
pathophysiology of which is strongly linked to impairments in serotonin (5-HT) …
The effects of microglia‐and astrocyte‐derived factors on neurogenesis in health and disease
Hippocampal neurogenesis continues throughout life and has been suggested to play an
essential role in maintaining spatial cognitive function under physiological conditions. An …
essential role in maintaining spatial cognitive function under physiological conditions. An …
Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a …
B Leonard, M Maes - Neuroscience & Biobehavioral Reviews, 2012 - Elsevier
This paper reviews that cell-mediated-immune (CMI) activation and inflammation contribute
to depressive symptoms, including anhedonia; anxiety-like behaviors; fatigue and somatic …
to depressive symptoms, including anhedonia; anxiety-like behaviors; fatigue and somatic …
Novel drug developmental strategies for treatment‐resistant depression
Major depressive disorder is a leading cause of disability worldwide. Because conventional
therapies are ineffective in many patients, novel strategies are needed to overcome …
therapies are ineffective in many patients, novel strategies are needed to overcome …
Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives
Rationale The chronic mild stress (CMS) paradigm was first described almost 40 years ago
and has become a widely used model in the search for antidepressant drugs for major …
and has become a widely used model in the search for antidepressant drugs for major …
Animal models of depression: molecular perspectives
V Krishnan, EJ Nestler - Molecular and functional models in …, 2011 - Springer
Much of the current understanding about the pathogenesis of altered mood, impaired
concentration and neurovegetative symptoms in major depression has come from animal …
concentration and neurovegetative symptoms in major depression has come from animal …