Molecular dynamics (MD) simulations have become increasingly useful in the modern drug
development process. In this review, we give a broad overview of the current application …

Highlights•Tau plays an important part in the formation of axonal microtubules.•
Phosphorylated tau (P-tau) plays an aberrant part in causing Alzheimer's disease.•P-tau is a …

Background The microtubule associated protein Tau (MAPT) promotes assembly and
interaction of microtubules with the cytoskeleton, impinging on axonal transport and synaptic …

Tau proteins not only have many important biological functions but also are associated with
several neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease …

The MAPT gene encoding the microtubule-associated protein tau can generate multiple
isoforms by alternative splicing giving rise to proteins which are differentially expressed in …

The full utilization of plant biomass for the production of energy and novel materials often
involves high temperature treatment. Examples include melt spinning of lignin for …

Abstract Characterization of biopolymers in both dry and weakly hydrated amorphous states
has implications for the pharmaceutical industry since it provides understanding of the effect …

Axonal cytoskeletal components of neuron have been studied and modeled by using
different approaches. The axonal cytoskeleton comprises of microtubules (MTs), which …

Protein surface hydration is critical to the protein's structural properties and biological
activities. However, it is still unknown whether the hydration shell is intrinsically connected …

Antifreeze glycoproteins (AFGPs) inhibit ice recrystallization by a mechanism remaining
largely elusive. The dynamics of AFGPs' hydration water and its involvement in the …