P-TEFb (CycT1: Cdk9), the metazoan RNA polymerase II Ser2 C-terminal domain (CTD)
kinase, regulates transcription elongation at many genes and integrates mRNA synthesis …

Abstract The Tousled-like kinases (TLKs) are an evolutionarily conserved family of serine–
threonine kinases that have been implicated in DNA replication, DNA repair, transcription …

Plants and animals mediate early steps of the innate immune response through pathogen
recognition receptors (PRRs). PRRs commonly associate with or contain members of a …

Environmental agents like ionizing radiation (IR) and chemotherapeutic drugs can cause
severe damage to the DNA, often in the form of double-strand breaks (DSBs). Remaining …

Germ cell development in C. elegans requires that the X chromosomes be globally silenced
during mitosis and early meiosis. We previously found that the nuclear proteins MES-2, MES …

Many viruses subvert the cellular interferon (Ifn) system with so-called Ifn antagonists.
Bunyamwera virus (BUNV) belongs to the family Bunyaviridae and is transmitted by …

Background The processes through which the germline maintains its continuity across
generations has long been the focus of biological research. Recent studies have suggested …

The carpel is the female reproductive organ specific to flowering plants. We aim to define the
genes that controlled carpel development in the common ancestor of this group as a step …

Set2 methylation of histone H3 at lysine 36 (K36) has recently been shown to be associated
with RNA polymerase II (Pol II) elongation in Saccharomyces cerevisiae. However, whether …

The Tousled-like kinases 1 and 2 (TLK1/2) control histone deposition through the ASF1
histone chaperone and influence cell cycle progression and genome maintenance, yet the …