Lipids are crucial components of cellular function owing to their role in membrane formation,
intercellular signaling, energy storage, and homeostasis maintenance. In the brain, lipid …

Advancements in computer science and software engineering have greatly facilitated mass
spectrometry (MS)-based untargeted metabolomics. Nowadays, gigabytes of metabolomics …

Little is known about the critical metabolic changes that neural cells have to undergo during
development and how temporary shifts in this program can influence brain circuitries and …

Selenium (Se) is a trace element crucial for human health. Recently, the impact of Se
supplementation on gut microbiota has been pointed out as well as its influence on the …

Abstract Introduction Type 1 diabetes (T1D) causes cognitive decline and has been
associated with brain metabolic disorders, but its potential molecular mechanisms remain …

While a number of methods are available for analyzing lipids, unbiased untargeted
lipidomics with high coverage remains a challenge. In this work, we report a study of isotope …

Flavonoid represents a significant class of secondary metabolites in Pu-erh tea with benefits
to human health. For a rapid and complete discovery of such compounds, we established a …

The heart contracts incessantly and requires a constant supply of energy, utilizing numerous
metabolic substrates, such as fatty acids, carbohydrates, lipids, and amino acids, to supply …

The milk fat globule membrane (MFGM) appears to play an important role in infant
neurocognitive development; however, its mechanism (s) of action remains unclear. This …

Malondialdehyde (MDA) has long been served as a crucial indicator for assessing cellular
oxidative stress levels. In this study, we introduce a new approach to determine cellular MDA …