The opposing actions of histone acetyltransferases (HATs) and histone deacetylases
(HDACs) allow gene expression to be exquisitely regulated through chromatin remodelling …

Chemists, like artists, are able to construct new threedimensional objects, molecules and
materials that exist only in the mind of a person. I became interested in creating novel …

Recognition of the DNA minor groove by pyrrole-imidazole polyamides - ScienceDirect Skip
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DNA has for many years been the traditional target for chemotherapeutic intervention1 in
human cancers, especially for those where high proliferation rates of some tumour cell types …

Gene expression is regulated by genomic enhancers that recruit transcription factors and
cofactors to activate transcription from target core promoters. Over the past years, thousands …

The synthetic biology toolkit contains a growing number of parts for regulating transcription
and translation, but very few that can be used to control protein association. Here we report …

The versatile coiled-coil protein motif is widely used to induce and control macromolecular
interactions in biology and materials science. Yet the types of interaction patterns that can be …

This book provides basic principles of multivalent interactions found in biological systems as
well as an up-to-date and thorough coverage in design concepts, syntheses, and biological …

Sequence-specificity is the key to effective genetic targeting. With specificity, targeted genes
can be manipulated in multiple ways; without it, gene therapy agents become loose canons …

In the post genome era it will soon be possible to associate a specific tumor type with a
specific gene expression profile and to define each molecular lesion characteristic of any …