[HTML][HTML] Pathogenic mechanisms of pancreatitis

M Manohar, AK Verma, SU Venkateshaiah… - World journal of …, 2017 - ncbi.nlm.nih.gov
Pancreatitis is inflammation of pancreas and caused by a number of factors including
pancreatic duct obstruction, alcoholism, and mutation in the cationic trypsinogen gene …

Sex-related differences of acute and chronic pancreatitis in adults

M Drake, SJM Dodwad, J Davis, LS Kao, Y Cao… - Journal of clinical …, 2021 - mdpi.com
The incidence of acute and chronic pancreatitis is increasing in the United States. Rates of
acute pancreatitis (AP) are similar in both sexes, but chronic pancreatitis (CP) is more …

Extracellular SQSTM1 exacerbates acute pancreatitis by activating autophagy-dependent ferroptosis

L Yang, F Ye, J Liu, DJ Klionsky, D Tang, R Kang - Autophagy, 2023 - Taylor & Francis
Acute pancreatitis (AP) is an abdominal inflammatory disease initiated by damaged
pancreatic acinar cells and developed by systemic inflammation. SQSTM1 (sequestosome …

Experimental acute pancreatitis models: history, current status, and role in translational research

X Yang, L Yao, X Fu, R Mukherjee, Q Xia… - Frontiers in …, 2020 - frontiersin.org
Acute pancreatitis is a potentially severe inflammatory disease that may be associated with a
substantial morbidity and mortality. Currently there is no specific treatment for the disease …

Acinar cell NLRP3 inflammasome and gasdermin D (GSDMD) activation mediates pyroptosis and systemic inflammation in acute pancreatitis

L Gao, X Dong, W Gong, W Huang… - British journal of …, 2021 - Wiley Online Library
Background and Purpose Pyroptosis is a lytic form of pro‐inflammatory cell death
characterised as caspase 1 dependent with canonical NLRP3 inflammasome‐induced …

Therapeutic potential of citrulline as an arginine supplement: a clinical pharmacology review

J Rashid, SS Kumar, KM Job, X Liu, CD Fike… - Pediatric Drugs, 2020 - Springer
Supplemental arginine has shown promise as a safe therapeutic option to improve
endogenous nitric oxide (NO) regulation in cardiovascular diseases associated with …

Comprehensive review on the pathogenesis of hypertriglyceridaemia-associated acute pancreatitis

M Qiu, X Zhou, M Zippi, H Goyal, Z Basharat… - Annals of …, 2023 - Taylor & Francis
It is well known, that the inflammatory process that characterizes acute pancreatitis (AP) can
lead to both pancreatic damage and systemic inflammatory response syndrome (SIRS) …

Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental …

PJ Hegyi, A Soós, E Tóth, A Ébert, V Venglovecz… - Scientific Reports, 2021 - nature.com
Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an
early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were …

Multi-dimensional metabolomic profiling reveals dysregulated ornithine metabolism hallmarks associated with a severe acute pancreatitis phenotype

J Yang, N Shi, S Wang, M Wang, Y Huang, Y Wang… - Translational …, 2024 - Elsevier
To reveal dysregulated metabolism hallmark that was associated with a severe acute
pancreatitis (SAP) phenotype. In this study, LC-MS/MS-based targeted metabolomics was …

The circadian clock protects against ferroptosis-induced sterile inflammation

Y Liu, Y Wang, J Liu, R Kang, D Tang - Biochemical and Biophysical …, 2020 - Elsevier
The circadian clock, a biochemical oscillator, plays a fundamental role in health and
diseases. Ferroptosis, a type of regulated cell death driven by oxidative stress, is a …