Potential of copper and copper compounds for anticancer applications

P Ji, P Wang, H Chen, Y Xu, J Ge, Z Tian, Z Yan - Pharmaceuticals, 2023 - mdpi.com
Inducing cancer cell death has always been a research hotspot in life sciences. With the
continuous deepening and diversification of related research, the potential value of metal …

Role of oxidative stress in the pathogenesis of atherothrombotic diseases

G Petrucci, A Rizzi, D Hatem, G Tosti, B Rocca… - Antioxidants, 2022 - mdpi.com
Oxidative stress is generated by the imbalance between reactive oxygen species (ROS)
formation and antioxidant scavenger system's activity. Increased ROS, such as superoxide …

Ablation of CaMKIIδ oxidation by CRISPR-Cas9 base editing as a therapy for cardiac disease

S Lebek, F Chemello, XM Caravia, W Tan, H Li, K Chen… - Science, 2023 - science.org
CRISPR-Cas9 gene editing is emerging as a prospective therapy for genomic mutations.
However, current editing approaches are directed primarily toward relatively small cohorts of …

Mammalian integrated stress responses in stressed organelles and their functions

H Lu, N Koju, R Sheng - Acta Pharmacologica Sinica, 2024 - nature.com
The integrated stress response (ISR) triggered in response to various cellular stress enables
mammalian cells to effectively cope with diverse stressful conditions while maintaining their …

Mitochondrial unfolded protein response and integrated stress response as promising therapeutic targets for mitochondrial diseases

H Lu, X Wang, M Li, D Ji, D Liang, C Liang, Y Liu… - Cells, 2022 - mdpi.com
The development and application of high-throughput omics technologies have enabled a
more in-depth understanding of mitochondrial biosynthesis metabolism and the …

Integrating UPLC-Q-Exactive Orbitrap/MS, network pharmacology and experimental validation to reveal the potential mechanism of Tibetan medicine Rhodiola …

N Xing, J Qin, D Ren, Q Du, Y Li, J Mi, F Zhang… - Journal of …, 2023 - Elsevier
Ethnopharmacology relevance Rhodiola granules (RG) is a traditional Tibetan medicine
prescription that can be used to improve the symptoms of ischemia and hypoxia in …

Mitochondrial quality control in cardiac ischemia/reperfusion injury: new insights into mechanisms and implications

Y Bai, J Wu, Z Yang, X Wang, D Zhang, J Ma - Cell Biology and Toxicology, 2023 - Springer
The current effective method for the treatment of myocardial infarction is timely restoration of
the blood supply to the ischemic area of the heart. Although reperfusion is essential for …

Protective effects of Pt-NC single-atom nanozymes against myocardial ischemia-reperfusion injury

T Ye, C Chen, D Wang, C Huang, Z Yan… - Nature …, 2024 - nature.com
Effective therapeutic strategies for myocardial ischemia/reperfusion (I/R) injury remain
elusive. Targeting reactive oxygen species (ROS) provides a practical approach to mitigate …

Inhibition of the integrated stress response reverses oxidative stress damage-induced postoperative cognitive dysfunction

L Jiang, R Dong, M Xu, Y Liu, J Xu, Z Ma… - Frontiers in Cellular …, 2022 - frontiersin.org
Postoperative cognitive dysfunction (POCD) is a common complication following anesthesia
and surgery that might lead to a decline in learning and memory. Oxidative stress damage is …

Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome

I Kutschka, E Bertero, C Wasmus, K Xiao… - Basic Research in …, 2023 - Springer
Barth Syndrome (BTHS) is an inherited cardiomyopathy caused by defects in the
mitochondrial transacylase TAFAZZIN (Taz), required for the synthesis of the phospholipid …