Mastocytosis is a hematologic neoplasm characterized by expansion and focal
accumulation of neoplastic mast cells (MC) in diverse organs, including the skin, bone …

Over the past few years, substantial advances have been made in understanding the
pathogenesis, evolution, and complexity of mast cell neoplasms. New diagnostic and …

The origin and functions of mast cells (MCs) have been debated since their description by
Paul Ehrlich in 1879. MCs have long been considered'reactive bystanders' and'amplifiers' in …

Mastocytosis is a heterogeneous group of neoplasms defined by a numerical increase and
accumulation of clonal mast cells (MCs) in various organ systems. The disease may present …

Mast cell activation (MCA) accompanies diverse physiologic and pathologic processes and
is one of the more frequently encountered conditions in medicine. MCA-related symptoms …

Mast cells are best recognized for their role in allergy and anaphylaxis, but increasing
evidence supports their role in neurogenic inflammation leading to pain and itch. Mast cells …

Mastocytosis is a term used to denote a heterogeneous group of conditions defined by the
expansion and accumulation of clonal (neoplastic) tissue mast cells in various organs. The …

Cutaneous mast cells (MCs) express Mas-related G protein–coupled receptor-X2
(MRGPRX2; mouse ortholog MrgprB2), which is activated by an ever-increasing number of …

Anaphylaxis is the most severe and frightening of the allergic reactions, placing patients at
high risk and demanding prompt recognition and immediate management by health care …

FcεRI is the primary receptor in mast cells that mediates allergic reactions by inducing rapid
release of mediators, an adaptive immune response that might have evolved as a host …