Pathogenicity and virulence of Staphylococcus aureus

GYC Cheung, JS Bae, M Otto - Virulence, 2021 - Taylor & Francis
Staphylococcus aureus is one of the most frequent worldwide causes of morbidity and
mortality due to an infectious agent. This pathogen can cause a wide variety of diseases …

The Role of Macrophages in Staphylococcus aureus Infection

GR Pidwill, JF Gibson, J Cole, SA Renshaw… - Frontiers in …, 2021 - frontiersin.org
Staphylococcus aureus is a member of the human commensal microflora that exists,
apparently benignly, at multiple sites on the host. However, as an opportunist pathogen it …

Staphylococcal manipulation of host immune responses

V Thammavongsa, HK Kim, D Missiakas… - Nature Reviews …, 2015 - nature.com
Staphylococcus aureus, a bacterial commensal of the human nares and skin, is a frequent
cause of soft tissue and bloodstream infections. A hallmark of staphylococcal infections is …

Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles

VP Vu, GB Gifford, F Chen, H Benasutti, G Wang… - Nature …, 2019 - nature.com
Deposition of complement factors (opsonization) on nanoparticles may promote clearance
from the blood by macrophages and trigger proinflammatory responses, but the mechanisms …

Control of phagocytosis by microbial pathogens

E Uribe-Querol, C Rosales - Frontiers in immunology, 2017 - frontiersin.org
Phagocytosis is a fundamental process of cells to capture and ingest foreign particles. Small
unicellular organisms such as free-living amoeba use this process to acquire food. In …

The complement system

JV Sarma, PA Ward - Cell and tissue research, 2011 - Springer
The complement system consists of a tightly regulated network of proteins that play an
important role in host defense and inflammation. Complement activation results in …

Complement evasion by human pathogens

JD Lambris, D Ricklin, BV Geisbrecht - Nature Reviews Microbiology, 2008 - nature.com
The human immune system has developed an elaborate network of cascades for dealing
with microbial intruders. Owing to its ability to rapidly recognize and eliminate …

Neutrophil-Mediated Phagocytosis of Staphylococcus aureus

KPM van Kessel, J Bestebroer… - Frontiers in …, 2014 - frontiersin.org
Initial elimination of invading Staphylococcus aureus from the body is mediated by
professional phagocytes. The neutrophil is the major phagocyte of the innate immunity and …

Antimicrobial Mechanisms of Macrophages and the Immune Evasion Strategies of Staphylococcus aureus

RS Flannagan, B Heit, DE Heinrichs - Pathogens, 2015 - mdpi.com
Habitually professional phagocytes, including macrophages, eradicate microbial invaders
from the human body without overt signs of infection. Despite this, there exist select bacteria …

Repair of Global Regulators in Staphylococcus aureus 8325 and Comparative Analysis with Other Clinical Isolates

S Herbert, AK Ziebandt, K Ohlsen… - Infection and …, 2010 - Am Soc Microbiol
The pathogenicity of Staphylococcus aureus strains varies tremendously (as seen with
animals). It is largely dependent on global regulators, which control the production of toxins …