Significance: Mitochondrial (mt) reticulum network in the cell possesses amazing
ultramorphology of parallel lamellar cristae, formed by the invaginated inner mitochondrial …

Preconditioning, postconditioning, and remote conditioning of the myocardium enhance the
ability of the heart to withstand a prolonged ischemia/reperfusion insult and the potential to …

The coexistence of two pools of ATP synthase in mitochondria has been largely neglected
despite in vitro indications for the existence of reversible active/inactive state transitions in …

Abstract Background and Aims The triggering factors of sepsis-induced myocardial
dysfunction (SIMD) are poorly understood and are not addressed by current treatments …

Non-exudative age-related macular degeneration (NE-AMD) is the leading blindness cause
in the elderly. Clinical and experimental evidence supports that early alterations in macular …

Succinate accumulates during myocardial ischemia and is rapidly oxidized during
reperfusion, leading to reactive oxygen species (ROS) production through reverse electron …

BACKGROUND: Adrenomedullin 2 (AM2) plays critical roles in regulating blood pressure
and fluid balance. However, the specific involvement of AM2 in cardiac hypertrophy has not …

Heart failure (HF) is a serious clinical syndrome and a serious development or advanced
stage of various heart diseases. Aging is an independent factor that causes pathological …

Glycation is a protein post-translational modification that can occur on lysine and arginine
residues as a result of a non-enzymatic process known as the Maillard reaction. This …

Physical inactivity impairs health by increasing morbidity. In childhood, modifiable risk
factors associated with cardiovascular pathologies and related to mitochondrial function and …