Self-assembled mRNA vaccines
Abstract mRNA vaccines have evolved from being a mere curiosity to emerging as COVID-
19 vaccine front-runners. Recent advancements in the field of RNA technology, vaccinology …
19 vaccine front-runners. Recent advancements in the field of RNA technology, vaccinology …
Regulation of the cell biology of antigen cross-presentation
JM Blander - Annual review of immunology, 2018 - annualreviews.org
Antigen cross-presentation is an adaptation of the cellular process of loading MHC-I
molecules with endogenous peptides during their biosynthesis within the endoplasmic …
molecules with endogenous peptides during their biosynthesis within the endoplasmic …
Evolution of the immune system influences speciation rates in teleost fishes
Teleost fishes constitute the most species-rich vertebrate clade and exhibit extensive genetic
and phenotypic variation, including diverse immune defense strategies. The genomic basis …
and phenotypic variation, including diverse immune defense strategies. The genomic basis …
Spotlight on TAP and its vital role in antigen presentation and cross-presentation
I Mantel, BA Sadiq, JM Blander - Molecular immunology, 2022 - Elsevier
In the late 1980s and early 1990s, the hunt for a transporter molecule ostensibly responsible
for the translocation of peptides across the endoplasmic reticulum (ER) membrane yielded …
for the translocation of peptides across the endoplasmic reticulum (ER) membrane yielded …
BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma
SD Bradley, Z Chen, B Melendez, A Talukder… - Cancer immunology …, 2015 - AACR
Oncogene activation in tumor cells induces broad and complex cellular changes that
contribute significantly to disease initiation and progression. In melanoma, oncogenic …
contribute significantly to disease initiation and progression. In melanoma, oncogenic …
Human dendritic cells in cancer
Dendritic cells (DCs) are currently considered to be of utmost importance for orchestrating
appropriate immune responses in vivo, and play critical roles in maintaining the distinction …
appropriate immune responses in vivo, and play critical roles in maintaining the distinction …
Increased antigen presentation efficiency by coupling antigens to MHC class I trafficking signals
Genetic modification of vaccines by linking the Ag to lysosomal or endosomal targeting
signals has been used to route Ags into MHC class II processing compartments for …
signals has been used to route Ags into MHC class II processing compartments for …
Control of dendritic cell cross-presentation by the major histocompatibility complex class I cytoplasmic domain
Dendritic cells (DCs) can present extracellularly derived antigens in the context of major
histocompatibility complex (MHC) class I molecules, a process called cross-presentation …
histocompatibility complex (MHC) class I molecules, a process called cross-presentation …
Priming of T cells by exogenous antigen cross-presented on MHC class I molecules
L Shen, KL Rock - Current opinion in immunology, 2006 - Elsevier
Cross-presentation is the process whereby bone-marrow-derived antigen-presenting cells
acquire, process and present exogenous antigen as peptides bound to MHC class I …
acquire, process and present exogenous antigen as peptides bound to MHC class I …
Immunodominance: a pivotal principle in host response to viral infections
A Akram, RD Inman - Clinical immunology, 2012 - Elsevier
We encounter pathogens on a daily basis and our immune system has evolved to mount an
immune response following an infection. An interesting phenomenon that has evolved in …
immune response following an infection. An interesting phenomenon that has evolved in …