BACKGROUND Biomolecules can serve as natural labels for microscopy by measuring their
molecular vibration spectra in living cells and tissues. However, the transition from …

Significance Photoacoustic imaging (PAI) enables the visualization of optical contrast with
ultrasonic imaging. It is a field of intense research, with great promise for clinical application …

We report wide-field polygon-scanning functional OR-PAM that for the first time achieves 1-
MHz A-line rate of oxygen saturation in vivo. We address two technical challenges. The first …

Lipid deposition inside the arterial wall is a key indicator of plaque vulnerability. An
intravascular photoacoustic (IVPA) catheter is considered a promising device for quantifying …

The vulnerable atherosclerotic plaque is believed to be at the root of the majority of acute
coronary events. Even though the exact origins of plaque vulnerability remain elusive, the …

An unmet need exists in high-speed and highly-sensitive intraoperative assessment of
breast cancer margin during conservation surgical procedures. Here, we demonstrate a …

Photoacoustic microscopy (PAM) offers unprecedented sensitivity to optical absorption and
opens a new window to study biological systems at multiple length-and timescales. In …

The quantized vibration of chemical bonds provides a way of detecting specific molecules in
a complex tissue environment. Unlike pure optical methods, for which imaging depth is …

The natural history of atherosclerosis is marked by changes in the lipid biochemistry in the
diseased arterial wall. As lesions become more vulnerable, different cholesterol species …

Mid-infrared photoacoustic microscopy can capture biochemical information without
staining. However, the long mid-infrared optical wavelengths make the spatial resolution of …