The role and mechanisms of action of microRNAs in cancer drug resistance

W Si, J Shen, H Zheng, W Fan - Clinical epigenetics, 2019 - Springer
MicroRNAs (miRNAs) are small non-coding RNAs with a length of about 19–25 nt, which
can regulate various target genes and are thus involved in the regulation of a variety of …

Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications

CM Wong, FHC Tsang, IOL Ng - Nature reviews Gastroenterology & …, 2018 - nature.com
Hepatocellular carcinoma (HCC) is a leading lethal malignancy worldwide. However, the
molecular mechanisms underlying liver carcinogenesis remain poorly understood. Over the …

MiR-199a-modified exosomes from adipose tissue-derived mesenchymal stem cells improve hepatocellular carcinoma chemosensitivity through mTOR pathway

G Lou, L Chen, C Xia, W Wang, J Qi, A Li… - Journal of Experimental …, 2020 - Springer
Abstract Background MiR-199a-3p (miR-199a) can enhance the chemosensitivity of
hepatocellular carcinoma (HCC). Because of the easy degradation of miRNA by direct …

miRNA deregulation in cancer cells and the tumor microenvironment

R Rupaimoole, GA Calin, G Lopez-Berestein, AK Sood - Cancer discovery, 2016 - AACR
Abstract miRNAs are a key component of the noncoding RNA family. The underlying
mechanisms involved in the interplay between the tumor microenvironment and cancer cells …

Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib: the EVOLVE-1 randomized clinical trial

AX Zhu, M Kudo, E Assenat, S Cattan, YK Kang… - Jama, 2014 - jamanetwork.com
Importance Aside from the multikinase inhibitor sorafenib, there are no effective systemic
therapies for the treatment of advanced hepatocellular carcinoma. Objective To assess the …

MET signalling: principles and functions in development, organ regeneration and cancer

L Trusolino, A Bertotti, PM Comoglio - Nature reviews Molecular cell …, 2010 - nature.com
The MET tyrosine kinase receptor (also known as the HGF receptor) promotes tissue
remodelling, which underlies developmental morphogenesis, wound repair, organ …

[HTML][HTML] MicroRNAs in apoptosis, autophagy and necroptosis

Z Su, Z Yang, Y Xu, Y Chen, Q Yu - Oncotarget, 2015 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are endogenous 22 nt non-coding RNAs that target mRNAs for
cleavage or translational repression. Numerous miRNAs regulate programmed cell death …

The emerging role of microRNAs and long noncoding RNAs in drug resistance of hepatocellular carcinoma

L Wei, X Wang, L Lv, J Liu, H Xing, Y Song, M Xie… - Molecular Cancer, 2019 - Springer
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and the
second most lethal human cancer. A portion of patients with advanced HCC can significantly …

[PDF][PDF] Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma

J Hou, L Lin, W Zhou, Z Wang, G Ding, Q Dong, L Qin… - Cancer cell, 2011 - cell.com
The full scale of human miRNome in specific cell or tissue, especially in cancers, remains to
be determined. An in-depth analysis of miRNomes in human normal liver, hepatitis liver, and …

[HTML][HTML] Guide for diagnosis and treatment of hepatocellular carcinoma

MH Attwa, SA El-Etreby - World journal of hepatology, 2015 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is ranked as the 5 th common type of cancer worldwide
and is considered as the 3 rd common reason for cancer-related deaths. HCC often occurs …