The Galα1, 3Galβ1, 4GlcNAc-R (α-Gal) epitope: a carbohydrate of unique evolution and clinical relevance

BA Macher, U Galili - Biochimica et Biophysica Acta (BBA)-General …, 2008 - Elsevier
In 1985, we reported that a naturally occurring human antibody (anti-Gal), produced as the
most abundant antibody (1% of immunoglobulins) throughout the life of all individuals …

The α‐gal epitope and the anti‐Gal antibody in xenotransplantation and in cancer immunotherapy

U Galili - Immunology and cell biology, 2005 - Wiley Online Library
The α‐gal epitope (Galα1‐3Galβ1‐(3) 4GlcNAc‐R) is abundantly synthesized on glycolipids
and glycoproteins of non‐primate mammals and New World monkeys by the glycosylation …

A useful guide to lectin binding: machine-learning directed annotation of 57 unique lectin specificities

D Bojar, L Meche, G Meng, W Eng, DF Smith… - ACS Chemical …, 2022 - ACS Publications
Glycans are critical to every facet of biology and medicine, from viral infections to
embryogenesis. Tools to study glycans are rapidly evolving; however, the majority of our …

Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells.

U Galili, SB Shohet, E Kobrin, CL Stults… - Journal of Biological …, 1988 - Elsevier
The study of the expression of alpha-galactosyl epitopes on various mammalian cells is of
particular interest, since as much as 1% of circulating IgG antibodies in humans interact with …

Evolutionary relationship between the natural anti-Gal antibody and the Gal alpha 1----3Gal epitope in primates.

U Galili, MR Clark, SB Shohet… - Proceedings of the …, 1987 - National Acad Sciences
Anti-Gal is a natural antibody, which constitutes as much as 1% of circulating IgG in humans
and displays a distinct specificity for the structure Gal alpha 1----3Gal. This glycosidic …

Oocyte Galα1, 3Gal Epitopes Implicated in Sperm Adhesion to the Zona Pellucida Glycoprotein ZP3 Are Not Required for Fertilization in the Mouse (∗)

AD Thall, P Malý, JB Lowe - Journal of Biological Chemistry, 1995 - ASBMB
The Galα1→ 3Gal structure is displayed on the zona pellucida glycoprotein ZP3 on murine
oocytes. This trisaccharide has been implicated in sperm-zona pellucida adhesive events …

[图书][B] Human blood groups: chemical and biochemical basis of antigen specificity

H Schenkel-Brunner - 2000 - books.google.com
As President and organiser of the 26th Congress of the International Society pf Blood
Transfusion'ISBT 2000', I am pleased to introduce this work on the biochemistry of human …

Lectins, versatile proteins of recognition: a review

JF Kennedy, PMG Palva, MTS Corella… - Carbohydrate …, 1995 - Elsevier
The nomenclature, structure, mode of action and applications of lectins are reviewed. This
group of proteinaceous macromolecules has the property of interacting with carbohydrates …

Mapping the lectin-like activity of tumor necrosis factor

R Lucas, S Magez, R De Leys, L Fransen… - Science, 1994 - science.org
Tumor necrosis factor (TNF), but not lymphotoxin (LT), is directly trypanolytic for salivarian
trypanosomes. This activity was not blocked by soluble 55-kilodalton and 75-kilodalton TNF …

[HTML][HTML] Amplifying immunogenicity of prospective Covid-19 vaccines by glycoengineering the coronavirus glycan-shield to present α-gal epitopes

U Galili - Vaccine, 2020 - Elsevier
The many carbohydrate chains on Covid-19 coronavirus SARS-CoV-2 and its S-protein form
a glycan-shield that masks antigenic peptides and decreases uptake of inactivated virus or S …