Magnetic resonance imaging (MRI) uses a large magnetic field and radio waves to generate
images of tissues in the body. Conventional MRI techniques have been developed to image …

Abstract Comprising~ 20% of the volume, water is a key determinant of the mechanical
behavior of cortical bone. It essentially exists in two general compartments: within pores and …

INTRODUCTION The components of bone assemble hierarchically to provide stiffness and
toughness. Deciphering the specific organization and relationship between bone's principal …

It is well known that organic molecules from the vertebrate extracellular matrix of calcifying
tissues are essential in structuring the apatite mineral. Here, we show that water also plays a …

It is well known that bone loss accompanies aging in both men and women and contributes
to skeletal fragility in the older population, but changes that occur to the bone tissue matrix …

Background Bone mass, geometry, and tissue material properties contribute to bone
structural integrity. Thus, bone strength arises from both bone quantity and quality. Bone …

D2O is commonly used as a solvent instead of H2O in spectroscopic studies of proteins, in
particular, in infrared and nuclear-magnetic-resonance spectroscopy. D2O is chemically …

Magnetic resonance imaging (MRI) is a non-invasive diagnostic imaging tool based on the
detection of protons into the tissues. This imaging technique is remarkable because of high …

Bone is a complex tissue constituted by a collagen matrix filled in with crystal of
hydroxyapatite (HAP). Bone mechanical properties are influenced by the collagen matrix …

Osteoporosis causes over 1.5 million fractures per year, costing about $15 billion annually in
the USA. Current guidelines utilize bone mineral density (BMD) to assess fracture risk; …