Acute kidney injury (AKI) and chronic kidney disease (CKD) are common kidney diseases in
clinics with high morbidity and mortality, but their pathogenesis is intricate. Tryptophan (Trp) …

A number of studies have assessed the impact of SARS-CoV-2 infection and COVID-19
severity on the metabolome of exhaled air, saliva, plasma, and urine to identify diagnostic …

Kidney transplantation significantly improves the survival of patients with end-stage kidney
disease (ESKD) compared to other forms of kidney replacement therapy. However, kidney …

Chronic kidney disease (CKD) affects approximately 12% of the global population, posing a
significant health threat. Inflammation plays a crucial role in the uremic phenotype of non …

Hyperuricemia (HUA) is a common complication of chronic kidney disease (CKD).
Conversely, HUA can promote the disease progression of CKD. However, the molecular …

Alzheimer disease, the leading cause of dementia, and polycystic ovary syndrome, one of
the most prevalent female endocrine disorders, appear to be unrelated conditions. However …

Background/Objectives: Asymptomatic carotid artery stenosis is usually detected by
physicians in patients, coincidentally, during an ultrasound examination of the neck …

The kynurenine pathway (KP) serves as the primary route for tryptophan metabolism in most
mammalian organisms, with its downstream metabolites actively involved in various …

Background: Chemotherapy resistance is a barrier to effective cancer prognoses. Cisplatin
(CDDP) resistance is a major challenge for esophageal cancer (EC) therapy. A deeper …

Introduction Uremic toxins contributing to increased risk of death remain largely unknown.
We used untargeted metabolomics to identify plasma metabolites associated with mortality …