Functional pancreatic islet beta cells are essential to ensure glucose homeostasis across
species from zebrafish to humans. These cells show significant heterogeneity, and emerging …

Pancreatic beta cells synthesize and secrete the neurotransmitter GABA (γ-aminobutyric
acid) as a paracrine and autocrine signal to help regulate hormone secretion and islet …

Modern omics techniques reveal molecular structures and cellular networks of tissues and
cells in unprecedented detail. Recent advances in single cell analysis have further …

Inhibition of microRNAs (miRNAs) essential for pancreatic β-cell biology (eg, miR-375)
results in β-cell failure and diabetes in rodent models. Whether the downregulation of …

Pancreatic β cells actively respond to glucose fluctuations through regulating insulin
processing and secretion. However, how this process is elaborately tuned in circumstance of …

Insulin is a peptide hormone secreted from pancreatic beta cells to regulate blood glucose
homeostasis. Maturation of active insulin occurs within insulin secretory granules (ISG) by …

Live imaging techniques have revolutionized our understanding of paracrine signaling, a
crucial form of cell-to-cell communication in biological processes. This review examines …

Type 2 diabetes (T2D) is one of the prominent causes of morbidity and mortality in the
United States and beyond, reaching global pandemic proportions. One hallmark of T2D is …

Over the course of the last few decades it has become clear that many neurodevelopmental
and neurodegenerative disorders have a synaptic defect, which contributes to pathogenicity …

Regulated exocytosis is a process by which cargo, which is stored in secretory granules
(SGs), is released in response to a secretory trigger. Regulated exocytosis is fundamental …