Cell therapy in the cornea: the emerging role of microenvironment

G Suanno, VG Genna, E Maurizi, AA Dieh… - Progress in Retinal and …, 2024 - Elsevier
The cornea is an ideal testing field for cell therapies. Its highly ordered structure, where
specific cell populations are sequestered in different layers, together with its accessibility …

[HTML][HTML] Biomedical Application of MSCs in Corneal Regeneration and Repair

MP De Miguel, M Cadenas-Martin, M Stokking… - International Journal of …, 2025 - mdpi.com
The World Health Organization estimates that approximately 285 million people suffer from
visual impairments, around 5% of which are caused by corneal pathologies. Currently, the …

[HTML][HTML] Human corneal stromal stem cells express anti-fibrotic microRNA-29a and 381-5p–A robust cell selection tool for stem cell therapy of corneal scarring

GHF Yam, T Yang, ML Geary, M Santra… - Journal of Advanced …, 2023 - Elsevier
Introduction Corneal blindness due to scarring is treated with corneal transplantation.
However, a global problem is the donor material shortage. Preclinical and clinical studies …

A novel transgenic mouse model for corneal scar visualization

I Khandaker, JL Funderburgh, ML Geary… - Experimental eye …, 2020 - Elsevier
Corneal opacities affect vision for millions of individuals worldwide. Fibrotic scar tissues
accumulate in reaction to inflammatory responses and remain permanently in corneal …

Transcriptomic profiling of human limbus-derived stromal/mesenchymal stem cells—novel mechanistic insights into the pathways involved in corneal wound healing

F Tavakkoli, M Damala, MA Koduri… - International Journal of …, 2022 - mdpi.com
Limbus-derived stromal/mesenchymal stem cells (LMSCs) are vital for corneal homeostasis
and wound healing. However, despite multiple pre-clinical and clinical studies reporting the …

The Human Cornea: Unraveling Its Structural, Chemical, and Biochemical Complexities

AK Raut, S Mohapatra, G SiddiquI, SK Rajak… - Chemistry & … - Wiley Online Library
The cornea, the transparent part of the anterior eye, is vital for light refraction and vision. This
review examines the intricate chemical and biochemical interactions essential for …

[HTML][HTML] Successful restoration of corneal surface integrity with a tissue-engineered allogeneic implant in severe keratitis patients

C González-Gallardo, J Martínez-Atienza… - Biomedicine & …, 2023 - Elsevier
Objectives Corneal diseases are among the main causes of blindness, with approximately
4.6 and 23 million patients worldwide suffering from bilateral and unilateral corneal …