The problem of antibiotic resistance is on the rise, with multidrug-resistant strains emerging
even to the last resort antibiotics. The drug discovery process is often stalled by stringent cut …

The accelerated appearance of drug-resistant bacteria poses an ever-growing threat to
modern medicine's capacity to fight infectious diseases. Gram-positive species such as …

Biofilm-mediated wound infections pose a significant challenge due to the limitations of
conventional antibiotics, which often exhibit narrow-spectrum activity, fail to eliminate …

In the context of peptide drug development, glycosylation plays a pivotal role. Accordingly, L-
type peptides were synthesized predicated upon the PD-1/PD-L1 blocker DPPA-1 …

Highlights•Glycopeptide antibiotics are last-resort antibiotics against drug-resistant
bacteria.•Chemical GPA modifications can be used to overcome bacterial resistance.• …

Covering: 2015 to 2022 Staphylococcus aureus (S. aureus) is responsible for several
community and hospital-acquired infections with life-threatening complications such as …

Vancomycin, a blockbuster antibiotic of the glycopeptide class, has been a life-saving
therapeutic against multidrug-resistant Gram-positive infections. The emergence of …

De novo drug development is an extremely complex, time-consuming and costly task.
Urgent needs for therapies of various diseases have greatly accelerated searches for more …

Gram-positive (G+) and Gram-negative (G–) bacteria require considerable differences in
their therapeutic strategies. Thus, the development of highly efficient techniques for …

Background As we entered the third year of this pandemic, since the World Health
Organisation (WHO) declared in March 2020 the novel coronavirus severe acute respiratory …