KISS1 metastasis suppressor in tumor dormancy: a potential therapeutic target for metastatic cancers?
Present therapeutic approaches do not effectively target metastatic cancers, often limited by
their inability to eliminate already-seeded non-proliferative, growth-arrested, or therapy …
their inability to eliminate already-seeded non-proliferative, growth-arrested, or therapy …
The kisspeptin (KiSS-1)/GPR54 system in cancer biology
A Makri, N Pissimissis, P Lembessis… - Cancer treatment …, 2008 - Elsevier
Kisspeptin (KiSS-1) gene, initially described as a melanoma metastasis suppressor gene,
encodes a number of peptides (kp-54, kp-14, kp-13, kp-10), which are endogenous ligands …
encodes a number of peptides (kp-54, kp-14, kp-13, kp-10), which are endogenous ligands …
[HTML][HTML] Kisspeptin/KISS1R system in breast cancer
D Cvetković, AV Babwah, M Bhattacharya - Journal of Cancer, 2013 - ncbi.nlm.nih.gov
Kisspeptins (KP), peptide products of the kisspeptin-1 (KISS1) gene are the endogenous
ligands for a G protein-coupled receptor (GPCR)-KP receptor (KISS1R). KISS1R couples to …
ligands for a G protein-coupled receptor (GPCR)-KP receptor (KISS1R). KISS1R couples to …
Predicting neuroendocrine tumor (carcinoid) neoplasia using gene expression profiling and supervised machine learning
BACKGROUND: A more accurate taxonomy of small intestinal (SI) neuroendocrine tumors
(NETs) is necessary to accurately predict tumor behavior and prognosis and to define …
(NETs) is necessary to accurately predict tumor behavior and prognosis and to define …
Activation of Rho and Rho-associated kinase by GPR54 and KiSS1 metastasis suppressor gene product induces changes of cell morphology and contributes to …
JM Navenot, N Fujii, SC Peiper - Molecular pharmacology, 2009 - ASPET
The mechanism of action of the metastasis suppressor KiSS1 and its receptor GPR54 is still
incompletely characterized. Although the loss of KiSS1 expression by tumor cells has been …
incompletely characterized. Although the loss of KiSS1 expression by tumor cells has been …
The role of kisspeptin system in cancer biology
M Stathaki, ME Stamatiou, G Magioris… - Critical reviews in …, 2019 - Elsevier
Kisspeptins are a family of neuropeptides that are known to be critical in puberty initiation
and ovulation. Apart from that kisspeptin derived peptides (KPs) are also known for their …
and ovulation. Apart from that kisspeptin derived peptides (KPs) are also known for their …
KiSS1 metastasis suppressor gene product induces suppression of tyrosine kinase receptor signaling to Akt, tumor necrosis factor family ligand expression, and …
JM Navenot, N Fujii, SC Peiper - Molecular pharmacology, 2009 - ASPET
The powerful metastasis suppressor function of KiSS1 gene products has been
demonstrated in both clinical studies and experimental models, but its mechanism is still …
demonstrated in both clinical studies and experimental models, but its mechanism is still …
Uveal melanoma dormancy: an acceptable clinical endpoint?
PL Blanco, LA Lim, C Miyamoto… - Melanoma Research, 2012 - journals.lww.com
Uveal melanoma is a rare but life-threatening malignancy. Over the past decades, the
morbidity of uveal melanoma has been markedly reduced as a result of advances in the …
morbidity of uveal melanoma has been markedly reduced as a result of advances in the …
KiSS1 and its G-protein-coupled receptor GPR54 in cancer development and metastasis
KiSS1 and its cognate G-protein-coupled receptor, GPR54, have diverse functions. While
KiSS1 and GPR54 have been intensively studied in physiology, their role in cancer is still …
KiSS1 and GPR54 have been intensively studied in physiology, their role in cancer is still …
Role of the tumor microenvironment in regulating the anti-metastatic effect of KISS1
KISS1, a metastasis suppressor gene, has been shown to block metastasis without affecting
primary tumor formation. Loss of KISS1 leads to invasion and metastasis in multiple cancers …
primary tumor formation. Loss of KISS1 leads to invasion and metastasis in multiple cancers …