Neuromelanin, aging, and neuronal vulnerability in Parkinson's disease

M Vila - Movement Disorders, 2019 - Wiley Online Library
Neuromelanin, a dark brown intracellular pigment, has long been associated with
Parkinson's disease (PD). In PD, neuromelanin‐containing neurons preferentially …

Dysregulation of tyrosinase activity: a potential link between skin disorders and neurodegeneration

W Jin, SJ Stehbens, RT Barnard… - Journal of Pharmacy …, 2024 - academic.oup.com
Objectives The co-occurrence of melanoma and Parkinson's disease (PD) is higher than
expected. We review the relationship between melanoma and PD, then proffer a hypothesis …

Genetically modified E. Coli secreting melanin (E. melanin) activates the astrocytic PSAP-GPR37L1 pathway and mitigates the pathogenesis of Parkinson's disease

W Kong, Y Liu, P Ai, Y Bi, C Wei, X Guo, Z Cai… - Journal of …, 2024 - Springer
The characteristic neuropathology of Parkinson's disease (PD) involves the abnormal
accumulation of phosphorylated α-synuclein (αSyn), as well as a significant decrease in …

[HTML][HTML] Pleiotropic Potential of Evernia prunastri Extracts and Their Main Compounds Evernic Acid and Atranorin: In Vitro and In Silico Studies

E Studzińska-Sroka, M Bulicz, M Henkel, N Rosiak… - Molecules, 2023 - mdpi.com
Evernia prunastri is a lichen widely distributed in the Northern Hemisphere. Its biological
properties still need to be discovered. Therefore, our paper focuses on studies of E. prunastri …

[HTML][HTML] Multi-Strain Probiotics Enhance the Bioactivity of Cascara Kombucha during Microbial Composition-Controlled Fermentation

TP Van, QK Phan, HP Quang, GB Pham… - … Nutrition and Food …, 2023 - ncbi.nlm.nih.gov
Kombucha is a widely consumed fermented tea beverage with diverse health benefits. In a
previous study, we demonstrated that the use of cascara as a substrate results in a special …

In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson's disease using neuromelanin-sensitive MRI: Replication in two cohorts

KS Hwang, J Langley, R Tripathi, XP Hu… - Plos one, 2023 - journals.plos.org
Patients with Parkinson's disease undergo a loss of melanized neurons in substantia nigra
pars compacta and locus coeruleus. Very few studies have assessed substantia nigra pars …

Ethyl pyruvate protects SHSY5Y cells against 6-hydroxydopamine-induced neurotoxicity by upregulating autophagy

Y Luo, K Sakamoto - PloS one, 2023 - journals.plos.org
Parkinson disease is a chronic progressive neurodegenerative disorder with a prevalence
that increases with age. The glycolytic end-product pyruvate, has antioxidant and …

[HTML][HTML] Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression

Y Wang, Q Wang, R Yu, Q Zhang, Z Zhang, H Li… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Studies indicate that mutant α-synuclein (mαSyn) is involved in the pathogenesis of
Parkinson's disease (PD). The mαSyn expression leads to the loss of dopaminergic neurons …

[引用][C] Avaliação do corpo estriado e da substância negra na doença de Parkinson através de imagens de ressonância magnética [T2w] e DaTSCAN SPECT.

LPM Mesquita - 2023