[HTML][HTML] CRISPR-edited stem cells in a patient with HIV and acute lymphocytic leukemia
The safety of CRISPR (clustered regularly interspaced short palindromic repeats)–based
genome editing in the context of human gene therapy is largely unknown. CCR5 is a …
genome editing in the context of human gene therapy is largely unknown. CCR5 is a …
The genetics and mechanisms of T-cell acute lymphoblastic leukemia
F Gianni, L Belver, A Ferrando - Cold Spring …, 2020 - perspectivesinmedicine.cshlp.org
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy
derived from early T-cell progenitors. The recognition of clinical, genetic, transcriptional, and …
derived from early T-cell progenitors. The recognition of clinical, genetic, transcriptional, and …
Initial diagnostic workup of acute leukemia: guideline from the College of American Pathologists and the American Society of Hematology
DA Arber, MJ Borowitz, M Cessna… - … of pathology & …, 2017 - meridian.allenpress.com
Context.—A complete diagnosis of acute leukemia requires knowledge of clinical
information combined with morphologic evaluation, immunophenotyping and karyotype …
information combined with morphologic evaluation, immunophenotyping and karyotype …
The molecular profile of adult T‐cell acute lymphoblastic leukemia: Mutations in RUNX1 and DNMT3A are associated with poor prognosis in T‐ALL
V Grossmann, C Haferlach… - Genes …, 2013 - Wiley Online Library
T‐cell acute lymphoblastic leukemia (T‐ALL) is an aggressive and heterogeneous disease.
The diagnosis is predominantly based on immunophenotyping. In addition to known …
The diagnosis is predominantly based on immunophenotyping. In addition to known …
Mutational spectrum of adult T-ALL
M Neumann, S Vosberg, C Schlee, S Heesch… - …, 2014 - pmc.ncbi.nlm.nih.gov
Novel target discovery is warranted to improve treatment in adult T-cell acute lymphoblastic
leukemia (T-ALL) patients. We provide a comprehensive study on mutations to enhance the …
leukemia (T-ALL) patients. We provide a comprehensive study on mutations to enhance the …
Clinical and molecular characterization of early T-cell precursor leukemia: a high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutations
M Neumann, S Heesch, N Gökbuget, S Schwartz… - Blood cancer …, 2012 - nature.com
A subgroup of pediatric acute T-lymphoblastic leukemia (T-ALL) was characterized by a
gene expression profile comparable to that of early T-cell precursors (ETPs) with a highly …
gene expression profile comparable to that of early T-cell precursors (ETPs) with a highly …
FLT3 mutations in early T-cell precursor ALL characterize a stem cell like leukemia and imply the clinical use of tyrosine kinase inhibitors
M Neumann, E Coskun, L Fransecky, LH Mochmann… - PloS one, 2013 - journals.plos.org
Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) has been identified as high-
risk subgroup of acute T-lymphoblastic leukemia (T-ALL) with a high rate of FLT3-mutations …
risk subgroup of acute T-lymphoblastic leukemia (T-ALL) with a high rate of FLT3-mutations …
Acute leukemias of ambiguous lineage in adults: molecular and clinical characterization
S Heesch, M Neumann, S Schwartz, I Bartram… - Annals of …, 2013 - Springer
Acute leukemias of ambiguous lineage represent a heterogeneous group of rare, poorly
characterized leukemias with adverse outcome. No larger studies have yet performed a …
characterized leukemias with adverse outcome. No larger studies have yet performed a …
[HTML][HTML] Multifaceted functions of the Wilms tumor 1 protein: From its expression in various malignancies to targeted therapy
Q Nian, Y Lin, J Zeng, Y Zhang, R Liu - Translational Oncology, 2025 - Elsevier
Abstract Wilms tumor 1 (WT1) is a multifaceted protein with dual functions, acting both as a
tumor suppressor and as a transcriptional activator of oncogenes. WT1 is highly expressed …
tumor suppressor and as a transcriptional activator of oncogenes. WT1 is highly expressed …
High accuracy mutation detection in leukemia on a selected panel of cancer genes
Z Kalender Atak, K De Keersmaecker, V Gianfelici… - PloS one, 2012 - journals.plos.org
With the advent of whole-genome and whole-exome sequencing, high-quality catalogs of
recurrently mutated cancer genes are becoming available for many cancer types. Increasing …
recurrently mutated cancer genes are becoming available for many cancer types. Increasing …