Phytotherapeutic alternatives for neurodegenerative dementias: Scientific review, discussion and therapeutic proposal

N Acero, T Ortega, V Villagrasa, G Leon… - Phytotherapy …, 2023 - Wiley Online Library
The incidence and prevalence of age‐related neurodegenerative dementias have been
increasing. There is no curative therapy and conventional drug treatment can cause …

[HTML][HTML] Interlacing the relevance of caspase activation in the onset and progression of Alzheimer's disease

PA Dhage, AA Sharbidre, SM Magdum - Brain Research Bulletin, 2023 - Elsevier
Caspases, a family of cysteine proteases is a renowned regulator of apoptosis. Members of
this family are responsible for the proteolytic dismantling of numerous cellular structures …

[PDF][PDF] Challenges and Future Prospects: A Benefaction of Phytoconstituents on Molecular Targets Pertaining to Alzheimer's Disease.

H Sharma, P Chandra - International Journal of Pharmaceutical …, 2024 - researchgate.net
Background: Many parts of the brain experience excruciating pain as a result of Alzheimer's
disease, a form of dementia. Cognitive processes and neuropsychiatric regulation are …

Traversing through the cell signaling pathways of neuroprotection by betanin: Therapeutic relevance to Alzheimer's Disease and Parkinson's Disease

BC Phukan, R Roy, R Paul, MK Mazumder, J Nath… - Metabolic Brain …, 2023 - Springer
Modulation of cell signaling pathways is the key area of research towards the treatment of
neurodegenerative disorders. Altered Nrf2-Keap1-ARE (Nuclear factor erythroid-2-related …

Phyto-nanotechnology: A novel beneficial strategy for Alzheimer's disease therapy

SC Ganguly, S Sangram, S Paul, M Kundu - Neurochemistry International, 2024 - Elsevier
Alzheimer's disease, a neurodegenerative condition, is characterized by the slow and
progressive deterioration of the cognitive functions of geriatric patients. It occurs due to …

Multiple regulation and targeting effects of borneol in the neurovascular unit in neurodegenerative diseases

N Chen, J Wen, Z Wang, J Wang - Basic & Clinical …, 2022 - Wiley Online Library
Efficient delivery of brain‐targeted drugs is highly important for the success of therapies in
neurodegenerative diseases. Borneol has several biological activities, such as anti …

PDGCL-DTI: Parallel Dual-channel Graph Contrastive Learning for Drug-Target Binding Prediction in Heterogeneous Networks

Q Zheng, X Tang, Y Meng, J Xu, X Zeng… - IEEE Journal of …, 2024 - ieeexplore.ieee.org
Predicting drug-target interactions (DTI) is critical for advancing drug discovery. However,
existing DTI approaches struggle with data imbalance and heterogeneous information. This …

An in-silico approach - molecular docking analysis of flavonoids against GSK-3β and TNF-α targets in Alzheimer's disease

S Viswanathan, R Sivaraj, AHR Vasanthi… - Journal of Receptors …, 2024 - Taylor & Francis
Abstract Introduction Drug development for Alzheimer's disease has one of the greatest
failure rates of any therapeutic field and AD is still incurable. Glycogen synthase kinase-3β is …

Aβ dissociation by pectolinarin may counteract against Aβ-induced synaptic dysfunction and memory impairment

JH Yi, E Cho, S Lee, KJ Kwon, S Lee, J Lee… - Biochemical …, 2023 - Elsevier
Alzheimer's disease (AD) is a degenerative brain disorder characterised by various
neurological symptoms, including memory impairment and mood disorders, associated with …

[HTML][HTML] Sociodemographic and clinical factors influencing serum potassium concentration: A retrospective cohort study

J Wang, M Jin, J Zheng, Y Chen, T Sun, Y Zheng… - Computational and …, 2024 - Elsevier
Background Self-care is crucial for maintaining the health and quality of life of individuals
undergoing physical examinations, especially those with abnormal test results because they …