[HTML][HTML] Advancements in the Development of Anti-SARS-CoV-2 Therapeutics

J Huang, Q Ma, Z Su, X Cheng - International Journal of Molecular …, 2024 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes
COVID-19, and so far, it has occurred five noteworthy variants of concern (VOC). SARS-CoV …

Role of N343 glycosylation on the SARS-CoV-2 S RBD structure and co-receptor binding across variants of concern

CM Ives, L Nguyen, CA Fogarty, AM Harbison… - Elife, 2024 - elifesciences.org
Glycosylation of the SARS-CoV-2 spike (S) protein represents a key target for viral evolution
because it affects both viral evasion and fitness. Successful variations in the glycan shield …

Tracking the immune response profiles elicited by the BNT162b2 vaccine in COVID-19 unexperienced and experienced individuals

E Galeota, V Bevilacqua, A Gobbini, P Gruarin… - Clinical …, 2024 - Elsevier
Multiple vaccines have been approved to control COVID-19 pandemic, with Pfizer/BioNTech
(BNT162b2) being widely used. We conducted a longitudinal analysis of the immune …

Development of a two-component recombinant vaccine for COVID-19

YS Sun, F Xu, HP Zhu, Y Xia, QM Li, YY Luo… - Frontiers in …, 2024 - frontiersin.org
Introduction Though COVID-19 as a public health emergency of international concern
(PHEIC) was declared to be ended by the WHO, it continues to pose a significant threat to …

1-L Transcription of SARS-CoV-2 Spike Protein S1 Subunit

J Nahalka - International Journal of Molecular Sciences, 2024 - mdpi.com
The COVID-19 pandemic prompted rapid research on SARS-CoV-2 pathogenicity.
Consequently, new data can be used to advance the molecular understanding of SARS …

[HTML][HTML] Beta Spike-Presenting SARS-CoV-2 Virus-like Particle Vaccine Confers Broad Protection against Other VOCs in Mice

I Ullah, K Symmes, K Keita, L Zhu, MW Grunst, W Li… - Vaccines, 2024 - mdpi.com
Virus-like particles (VLPs) are non-infectious and serve as promising vaccine platforms
because they mimic the membrane-embedded conformations of fusion glycoproteins on …

[HTML][HTML] Leveraging Walnut Somatic Embryos as a Biomanufacturing Platform for Recombinant Proteins and Metabolites

PA Zaini, KR Haddad, NG Feinberg, Y Ophir, S Nandi… - BioTech, 2024 - mdpi.com
Biomanufacturing enables novel sources of compounds with constant demand, such as food
coloring and preservatives, as well as new compounds with peak demand, such as …

[HTML][HTML] Booster Vaccination with BNT162b2 Improves Cellular and Humoral Immune Response in the Pediatric Population Immunized with CoronaVac

DA Díaz-Dinamarca, S Cárdenas-Cáceres, NA Muena… - Vaccines, 2024 - mdpi.com
The SARS-CoV-2 Omicron variant and its sublineages continue to cause COVID-19-
associated pediatric hospitalizations, severe disease, and death globally. BNT162b2 and …

Generación de un método de selección clonal específico de antígeno y su aplicación para la identificación de anticuerpos monoclonales contra el SARS-CoV-2

RQ MANZANARES - 2023 - riaa.uaem.mx
El sistema inmune tiene la capacidad de responder a una amplia variedad de antígenos al
generar un amplio repertorio de receptores de células B (BCR). Sin embargo, la generación …